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Archiv-Übersicht     Angebot Nr. 12276

Angebotsdatum: 19. September 2017
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: PhD Position - Epigenetic Characterization of Cancer Associated Fibroblasts

Institut: RWTH Aachen Medical School
Prof. Wolfgang Wagner
Pauwelsstrasse 20
52074 Aachen
Tel.: 0241 8088611   Fax.:
Bundesland: Nordrhein-Westfalen
Homepage: http://www.stemcellbiology.ukaachen.de
E-Mail Kontakt: mail

Beschreibung: The group Stem Cell Biology and Cellular Engineering at the Helmholtz-Institute for Biomedical Engineering is offering a position for a

Ph.D. student

Focus of this project is on epigenetic characterization of cancer associated fibroblasts (CAFs). These cells have crucial impact on tumorigenesis and metastasis. However, the cellular origin of CAFs and their epigenetic characteristics are largely unclear. We will analyze CAFs in hepatocellular carcinoma and myeloproliferative neoplasms to determine their clonal composition and differentiation potential. Genome wide DNA methylation profiles will be analyzed to determine disease-associated epigenetic modifications in CAFs, their cellular origin, and their frequency in tumor samples. RWTH Aachen University Medical School wants to strengthen research in oncology. The project is embedded into an IZKF-funded research onsortium "mesenchymal interactions and fibrogenic signalling in cancer development: molecular mechanisms in solid and hematologic neoplasms”.

We are looking for a highly motivated and ambitious PhD student with a strong background in cell biology. Experience in stem cell biology and/or epigenetics would be appreciated. Willingness for teamwork, the ability to work independently, and excellent English language skills are prerequisites.

We offer a highly interactive and well equipped environment in a team with international partners, a broad spectrum of methods, and a highly relevant topic.
Methoden: All relevant techniques are established in the lab (including culture expansion, differentiation assays, flow cytometry, immunofluorescence and confocal microscopy, qRT-PCR, blotting techniques, genetic modifications, microarray platforms, single cell RNA-seq, and epigenetic analysis with deep sequencing technology). Close collaboration with bioinformaticians is essential to integrate additional genetic and epigenetic datasets (AG Ivan Costa; http://costalab.org).
Anfangsdatum: 1. Januar 2018
Geschätzte Dauer: 3 years
Bezahlung: 1st year with 50% TV-L E13, 2nd and 3rd year 65% T
Papers: Link to Google Scholar: http://scholar.google.de/citations?user=sp5F7kEAAAAJ&hl=de&oi=ao

Link to Research Gate: https://www.researchgate.net/profile/Wolfgang_Wagner4
Sonstiges: The University RWTH Aachen supports women in science. Applications of handicapped applicants are encouraged.

Your application should include a cover letter which specifically emphasizes your interest in our work (in English), CV, and copies of the most important certificates. For additional questions please contact Prof. Dr. Dr. Wolfgang Wagner. Your application should be send by Email (wwagner@ukaachen.de) until October 15th, 2017.

We are looking forward to your application!