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Archiv-Übersicht     Angebot Nr. 12345

Angebotsdatum: 22. Juni 2017
Art der Stelle: Diplomarbeit
Fachgebiet: Biologie > Mikrobiologie
Titel des Themas: Microbiology-Internship at the University of Michigan – Ann Arbor

Institut: University of Michigan
Adresse:
Dr. rer. nat. Jan-Ulrik Dahl
830 N University Ave
48109 Ann Arbor
Tel.: 7349725974   Fax.:
Bundesland:
Homepage: http://sites.lsa.umich.edu/jakob-lab/
E-Mail Kontakt: mail

Beschreibung: We are seeking a highly motivated Master student with a Bachelor’s or equivalent degree in Biochemistry/ Microbiology/ Biotechnology/ Molecular Biology, who are interested in an internship position for the duration of 3-9 months. We provide the potential candidate with the opportunity to complete her/his master's or master's thesis in our lab (at least 6 months duration). The internship will be paid and the student can pick the starting date.

The Jakob lab is located at the University of Michigan, one of the top five public schools in the country, which provides an excellent research environment. The Jakob lab is part of the Department of Molecular, Cellular, & Developmental Biology, which consists of fifty-two faculty and over seventy Ph.D., students whose charge is to increase knowledge of living organisms. Our lab studies redox regulation and the role of oxidative stress in host defense and aging. Cellular responses to reactive oxygen species such as hypochlorous acid (HOCl, the active component of household bleach) are well known as critical factors in virulence of invading pathogens. Our research goal is to explore the role that HOCl stress response plays in medically important bacteria, particularly focusing on roles in colonization, inflammation, and pathogenesis. It is widely accepted that bacteria are critical determinants of human health, which becomes especially important in times of increasing resistance of pathogens to antibiotics. Ultimately, our research will lead to new therapeutic strategies that could either sensitize pathogenic bacteria to killing by the immune system or make health-promoting bacteria more robust.
Methoden:
Anfangsdatum: 22. Juni 2017
Geschätzte Dauer: 3-9 months
Bezahlung: please inquire within
Papers: Literature:

1) Dahl, J.U., M.J. Gray, D. Bazopoulou, F. Beaufay, J. Lempart, M.J. Koenigsknecht, Y. Wang, J.R. Baker, W.L. Hasler, V.B. Young, D. Sun & U. Jakob, (2017) The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation. Nat Microbiol 2: 16267.
2) Gray, M.J., W.Y. Wholey, N.O. Wagner, C.M. Cremers, A. Mueller-Schickert, N.T. Hock, A.G. Krieger, E.M. Smith, R.A. Bender, J.C. Bardwell & U. Jakob, (2014) Polyphosphate is a primordial chaperone. Mol Cell 53: 689-699.
3) Winter, J., M. Ilbert, P.C. Graf, D. Ozcelik & U. Jakob, (2008) Bleach activates a redox-regulated chaperone by oxidative protein unfolding. Cell 135: 691-701.
Sonstiges: We have a lot of experience working with German graduate and master students and will assist with the paperwork.

How to apply?

Please email CV, current transcript of classes taken, a short paragraph about what drives you to conduct research in the US and contact information for at least two references to Prof. Ursula Jakob (email: ujakob@umich.edu)

Contact Info:

Ursula Jakob, Ph.D.
Patricia S. Yaeger Collegiate Professor in Molecular, Cellular, and Developmental Biology

Dept. of Molecular, Cellular and Developmental Biology and Dept. of Biological Chemistry
University of Michigan and University of Michigan Medical School
830 N-University
Ann Arbor, MI 48109-1048
(office) 1-734-615-1286
(lab) 1-734-615-1957


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