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Archiv-Übersicht     Angebot Nr. 12404

Angebotsdatum: 3. August 2017
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Biochemie
Titel des Themas: Investigation of the role of the ubiquitin E3 ligase SIAH2 to the development of cor pulmonale

Institut: Institut für Biochemie
Prof. Lienhard Schmitz
Friedrichstrasse 24
35392 Giessen
Tel.:    Fax.:
Bundesland: Hessen
Homepage: http://https://www.uni-giessen.de/fbz/fb11/institute/biochemie/forschungbiochemie/agschmitz
E-Mail Kontakt: mail

Beschreibung: The Institute of Biochemistry (Medical Faculty) is inviting applications for a

PhD student (TV-H 13 / 65 %).

This project is carried out together with the Physiological Institute (University Giessen, Prof. Susanne Rohrbach) and investigates the role of the ubiquitin E3 ligase SIAH2 to the development of cor pulmonale. We have found that mice lacking the ubiquitin E3 ligase SIAH2 are largely protected mice from hypoxia-induced cor pulmonale. It will now be investigated whether heart-specific deletion of Siah2 protects against right ventricular hypertrophy (RVH). We will also assess whether ongoing RVH can be inhibited or even reversed by inducible ablation of Siah2. The molecular targets, signaling pathways and metabolic changes regulated by SIAH2 in the right ventricle will be identified and further characterized. Additionally, we will test the applicability of SIAH2 inhibitors for the prevention and treatment of RVH.
This project is funded by the CRC1213 and employs a battery of diffent methods from biochemistry/molecular biology and also uses mouse models (https://www.uni-giessen.de/forschung/einrichtungen/sfb/corpulmonale). Your profile: You have succesfully finished your Master or equivalent degree. You are highly self-motivated, ambitious and can work well in a highly active international research team, but also work on your own. The position is funded until June 2020, a prolongation is potentially possible. The university is an equal opportunity employer, and applications from women or candidates with children are encouraged. Applications of severely disabled with same suitability are preferred. Application deadline is end of August 2017.

Please send your CV, two names of reference and the further usual documents as one pdf-file to

Prof. M.L. Schmitz
Biochemical Institute
Friedrichstrasse 24
35392 Giessen (Germany)
e-Mail: lienhard.schmitz@biochemie.med.uni-giessen.de
Anfangsdatum: 3. August 2017
Geschätzte Dauer: 3 Jahre
Bezahlung: E13 65%
Papers: https://www.ncbi.nlm.nih.gov/pubmed/?term=schmitz+ml+Not+rock+Not+children+Not+aarhus+Or+Lienhard+Schmitz