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Archiv-Übersicht     Angebot Nr. 12405

Angebotsdatum: 4. August 2017
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Neurobiologie
Titel des Themas: Molecular analysis of neuronal differentiation during cortical development

Institut: Institute for Molecular Cell Biology, University of Münster
Adresse:
Prof. Andreas Püschel
Schlossplatz 5
48149 Münster
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
Homepage: http://www.imprs-mbm-cedad.mpg.de/index.php?page=project&id=22
E-Mail Kontakt: mail

Beschreibung: One position for a PhD student (TVL-13 65%) is available starting November 2017 or later to study neuronal differentiation using live cell imaging.
We are looking for highly motivated candidates with an interest in understanding fundamental questions of neurobiology at the molecular and cellular level. The differentiation of a polarized neuronal morphology and the radial migration of neurons are key events during development to establish the complex architecture of the mammalian neocortex. Defects in the signaling pathways that direct these processes disrupt cortical development and lead to neurodevelopmental diseases. We are interested in the molecular and cellular mechanisms that regulate these processes during development in mice. In particular, we are investigating how the regulation of intracellular transport processes and endo- and exocytosis is coupled to the formation of axons.
Applications can be sent by e-mail until September 1 to Prof. Andreas Püschel: apuschel@uni-muenster.de. Institute for Molecular Cell Biology, University of Münster, Schlossplatz 5, 48149 Münster, Germany.
Methoden: The project involves the functional analysis of signaling by GTPases and the development of novel tools to analyze intracellular transport by live cell imaging.
The project will employ a combination of molecular, cell biological, and genetic techniques in combination with life cell imaging to study differentiation in cultured neurons, organotypic slice cultures and knockout mice.
Experience in life cell imaging or the culture of neurons is an advantage but not required. The project is part of the Cluster of Excellence "Cells in Motion".
Anfangsdatum: 1. November 2017
Geschätzte Dauer: 3 years
Bezahlung: TVL-13 65%
Papers: Shah, B., Lutter, D., Tsytsyura, Y., Glyvuk, N., Sakakibara, A., Klingauf, J., and Püschel, A.W. (2017). Rap1 GTPases Are Master Regulators of Neural Cell Polarity in the Developing Neocortex. Cereb. Cortex 27, 1253–1269.

Shah, B., Lutter, D., Bochenek, M.L., Kato, K. Tsytsyura, Y., Glyvuk, N., Sakakibara, A., Klingauf, J., Adams, R.H., and Püschel, A.W. (2016). C3G/Rapgef1 is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development. PLoS One 11, e0154174.
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