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Archiv-Übersicht     Angebot Nr. 12428

Angebotsdatum: 21. August 2017
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Reconstitution of Cell Polarity and Morphogenesis

Institut: Max Planck Institut für molekulare Physiologie
Adresse:
Dr. rer. nat. Peter Bieling
Otto-Hahn-Str. 11
44227 Dortmund
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
Homepage: http://www.mpi-dortmund.mpg.de/research-groups/bieling
E-Mail Kontakt: mail

Beschreibung: The central goal of our research is to understand the mechanisms by which cells establish spatio-temporal patterns of signal network activity to co-ordinate dynamic cell shape changes through the cytoskeleton. This patterning mechanism is based on a complex interplay between signaling proteins, cytoskeletal components and the cell membrane.

We study (i) how signal networks can self-organize to generate patterns and (ii) how those patterns can be harnessed by cytoskeletal systems to drive shape changes. To investigate the fundamental principles of self-organization we are using minimal systems reconstituted from purified components.
Methoden: Research techniques applied in this project will include, but are not limited to:

- performing a wide variety of molecular biological and biochemical tasks (e.g. cloning, protein purification, labeling etc.)

- using advanced fluorescence microscopy techniques (TIRF and confocal microscopy, FRET-based imaging, single molecule methods etc.)

- developing advanced in vitro assays involving multi-protein and membrane reconstitution
Anfangsdatum: 21. August 2017
Geschätzte Dauer: 3-4 Years
Bezahlung:
Papers: 1. Bieling P. et al. (2016) Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin
Networks. Cell

2. Bieling P. et al. (2010) A minimal midzone protein module controls formation and length of antiparallel microtubule overlaps. Cell
Sonstiges:

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