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Archiv-Übersicht     Angebot Nr. 12429

Angebotsdatum: 21. August 2017
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: Cell biology and biochemistry of microtubule dynamics

Institut: Max-Planck-Insitut für molekulare Physiologie
Dr. rer. nat. Alexander Bird
Otto-Hahn-Str. 11
44227 Dortmund
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
Homepage: http://bird-lab.org/
E-Mail Kontakt: mail

Beschreibung: Precise control of microtubule dynamics and stability is critical for several cellular functions including chromosome segregation and cell division. Misregulation of microtubule stability during mitosis can result in chromosome missegregation and chromosomal instability, which can contribute to tumorigenesis. We have identified novel factors and pathways important for regulating microtubule stability in normal cells, while deregulated and impacting chromosomal instability in cancer cells. We are now elucidating the molecular mechanisms and regulation of these factors in time and space within cells, and the impact of their deregulation on chromosomal instability in the cancer context. We are also seeking to reconstitute these factors and pathways in vitro using purified components for both structural studies and functional studies on microtubule stabilization.
Methoden: We employ a variety of techniques spanning biochemistry and cell biology to answer these questions, including live cell fluorescence microscopy, CRISPR/Cas9 and genome modification for genetic analyses, and protein purification and interaction/activity analysis. Often projects also involve active collaboration within the department and institute for structural studies and quantitative proteomics to answer specific questions.
Anfangsdatum: 21. August 2017
Geschätzte Dauer: 3-4 years
Bezahlung: TV-L E13 (50-65%)
Papers: http://bird-lab.org/publications.html
Sonstiges: We are an international and socially and intellectually engaging lab. The working language in the lab and institute is English

A background and familiarity with molecular biology is required, although no specific experience with any technique is necessary. Previous experience in fluorescence microscopy, mammalian cell culture, protein biochemistry, and/or cloning/DNA modification techniques is beneficial but not required. Most importantly, the applicant must be enthusiastic with a developed ability to work independently and think critically, as well as to read, interpret, and apply scientific literature to the project. Candidates must also meet the criteria as designated by the International Max Planck Research School in Chemical and Molecular Biology (IMPRS-CMB) (https://imprs-cmb.mpg.de/).

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. Furthermore, the Max Planck Society seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.

To apply, please send

• a motivation letter (including a summary of previous research experience)
• a CV
• the names of at least 2 references that may be contacted

directly via email to alex.bird@mpi-dortmund.mpg.de,
preferably by September 30th, 2017.