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Archiv-Übersicht     Angebot Nr. 12464

Angebotsdatum: 13. September 2017
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Neurobiologie
Titel des Themas: Pre-synaptogenesis in mammalian auditory hair cells

Institut: Institute for Auditory Neuroscience & InnerEarLab
Adresse:
Dr. rer. nat. Christian Vogl
Robert-Koch-Str. 40
37075 Göttingen
Tel.:    Fax.:
Bundesland:
Homepage:
E-Mail Kontakt: mail

Beschreibung: Mammalian sound encoding relies on faithful and precise neurotransmission between cochlear inner hair cells (IHC) and afferent spiral ganglion neurons. To master this challenging task, the presynaptic active zones of IHCs are equipped with presynaptic specialisations – due to their morphology termed 'synaptic ribbons' – that facilitate high rates of vesicular release and subsequent replenishment, even during prolonged periods of ongoing stimulation. While the molecular architecture and function of ribbon-type active zones has been an area of intense research, the presynaptic development prior to hearing onset still remains enigmatic. Hence, this project will focus on developmental aspects of pre-synaptogenesis in auditory hair cells and aims to identify the key molecules, as well as the underlying cellular processes that determine the functional maturation and presynaptic plasticity of this high-throughput synapse.
Methoden: organotypic culture preparation, live-cell imaging, super-resolution microscopy (STED), electrophysiology, molecular biology, biochemistry
Anfangsdatum: 1. Januar 2018
Geschätzte Dauer: 3+ years
Bezahlung: Equivalent to E13/65%
Papers:
Sonstiges:

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