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Archiv-Übersicht     Angebot Nr. 12479

Angebotsdatum: 27. September 2017
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Exciting PhD Student Positions at IMPRS for Molecular Life Sciences, Munich

Institut: MPI of Biochemistry
Adresse:
Dr. rer. nat. Hans-Jörg Schäffer
Am KLopferspitz 18
82152 Munich-Martinsried
Tel.:    Fax.:
Bundesland: Bayern
Homepage: http://www.imprs-ls.mpg.de
E-Mail Kontakt: mail

Beschreibung: The International Max Planck Research School for Molecular Life Sciences: From Biological Structures to Neural Circuits (IMPRS-LS) currently has an open call for competitive PhD student positions.
IMPRS-LS brings together two renowned Max Planck Institutes, the MPI of Biochemistry and the MPI of Neurobiology as well as two leading partner-universities, the LMU and TUM, to deliver first class training for the world‘s most promising young scientists.

Situated in an outstanding research environment at the life science campus in Munich-Martinsried, the school’s research activities center around three distinct but well-connected research branches: Our students and their supervisors strive to uncover molecular mechanisms regulating biological processes, analyze the resulting complex biological systems and decipher the intricate network of neural circuits leading to corresponding behavioral responses.

More than 60 distinguished group leaders actively participate in the PhD program and offer challenging and cutting-edge PhD projects in the following areas:

• Biophysics & Bio-imaging
• Computational & Systems Biology
• Gene Regulation & DNA Biology
• Circuit Neuroscience & Neurodegeneration
• Protein Structure & Protein Folding
• Signaling & Immunology

Our truly international students enjoy dedicated training workshops, world-class research facilities and supervision from faculty members who are leaders in their respective fields. Combined with a focus on early independence in research, our PhD program ensures those aiming for a successful career in science have the very best starting platform.

The cosmopolitan city of Munich is at the forefront of scientific research in Germany and, situated in the heart of Bavaria, uniquely combines tradition with the modern age.

We invite highly qualified candidates with a strong commitment to basic science to apply.

Applicants should hold an MSc (or equivalent degree) with a strong background in biological sciences, neurosciences, biochemistry, biophysics, biotechnology or a related discipline.
Outstanding candidates with a first class BSc degree (or equivalent degree) are welcome to apply for the fast track option.
For more information, eligibility criteria and online application please visit our website: www.imprs-ls.de

Application is open NOW. Closing date for application is November 15, 2017. Accepted candidates may start research projects between March 2018 and October 2018.

Methoden:
Anfangsdatum: 1. März 2018
Geschätzte Dauer: 3-4 years
Bezahlung: TVöD 13 66%
Papers: Selected Publications:

Bäuerlein, F. J. B.; Saha, I.; Mishra, A.; Kalemanov, M.; Martinez-Sanchez, A.; Klein, R.; Dudanova, I.; Hipp, M. S.; Hartl, F. U.; Baumeister, W. et al.: In Situ Architecture and Cellular Interactions of PolyQ Inclusions. Cell (2017)

The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillère Q, Braunger K, Heuer A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R.
Science. 2016 Dec 16;354(6318):1431-1433.

Sun Z., Tseng H.-Y., Tan S., Senger F., Kurzawa L., Dedden D., Mizuno N., Wasik A.A., Thery M., Dunn A.R., and Fässler R. (2016). Kank family proteins activate Talin and reduce force transduction across integrins. Nature Cell Biol., 18: 941-953.

Choe, Y.-J.; Park, S.-H.; Hassemer, T.; Körner, R.; Vincenz-Donnelly, L.; Hayer-Hartl, M.; Hartl, F. U.: Failure of RQC machinery causes protein aggregation and proteotoxic stress. Nature 531 (7593), pp. 191 - 195 (2016)

Rieckmann, J. C.; Geiger, R.; Hornburg, D.; Wolf, T.; Kveler, K.; Jarrossay, D.; Sallusto, F.; Shen-Orr, S. S.; Lanzavecchia, A.; Mann, M. et al.: Social network architecture of human immune cells unveiled by quantitative proteomics. Nature Immunology 18 (5), pp. 583 - 593 (2017)

Laprell, F., Finkl, K. and Müller, J. Propagation of Polycomb-repressed chromatin requires sequence-specific recruitment to DNA. Science 356, 85-88.

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.
Scott DC, Rhee DY, Duda DM, Kelsall IR, Olszewski JL, Paulo JA, de Jong A, Ovaa H, Alpi AF, Harper JW*, Schulman BA*.
Cell. 2016 Aug 25;166(5):1198-1214

Orlando Argüello-Miranda, Ievgeniia Zagoriy, Valentina Mengoli, Julie Rojas, Katarzyna Jonak, Tugce Oz, Peter Graf and Wolfgang Zachariae(2017). Casein Kinase 1 Coordinates Cohesin Cleavage, Gametogenesis, and Exit from M Phase in Meiosis II. Developmental Cell 40, 37-52.

Roers, A., B. Hiller and V. Hornung. Recognition of Endogenous Nucleic Acids by the Innate Immune System. Immunity, 2016; 44: 739-54

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Andreeva L, Hiller , Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP
Nature. 2017 Sep 13.
Sonstiges: Please submit your application online using our online application tool at www.imprs-ls.de

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