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Archiv-Übersicht     Angebot Nr. 12493

Angebotsdatum: 6. Oktober 2017
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: The Role of Met Tyrosine Kinase Signaling in Dendritic Cells for Regulation of Cell Motility, Migration, and Immune Response

Institut: RWTH Aachen Medical School - Institute for Biomedical Engineering
Adresse:
Dr. rer. nat. Thomas Hieronymus
Pauwelsstr. 30
52078 Aachen
Tel.:    Fax.:
Bundesland:
Homepage: http://www.molcell.rwth-aachen.de
E-Mail Kontakt: mail

Beschreibung: The Institute for Biomedical Engineering, Department of Cell Biology, University Clinic RWTH Aachen, Germany is currently seeking for a student with a Master/Diploma degree in Biology, Biochemistry, Biomedicine, Biotechnology or related life sciences to fill an open

PhD student position

The position is offered as a temporary contract for 2 years with the option for extension and opens the opportunity to pursue a doctoral degree.

The project relates to the research on development and function of antigen-presenting dendritic cells (DCs) and their possible application for immunotherapy. DCs are critically involved in inflammatory diseases e.g. in the skin (psoriasis, eczema or contact dermatitis). In our previous studies, we have identified an essential function of the HGF receptor/Met-signaling pathway in DCs for their emigration from skin. In this DFG-funded project the impact of the Met receptor tyrosine kinase pathway in DCs on the regulation of cell motility, migration and immune response will be examined in more detail.

We are looking for highly motivated and ambitious PhD student with a background in cell biology. Knowledge in the field of immunology and particularly in DC biology and/or experience within the range of methods would be appreciated. The ability to work independently while being a team player, an outstanding commitment to succeed in research and a high level of English language skills are prerequisites.

Additional information can be found on our homepage www.molcell.rwth-aachen.de
Methoden: The successful candidate will apply state-of-the-art cellular and molecular methods (flow cytometry, western blotting, chromatin immune precipitation (ChIP), qPCR, microarray analysis) and microscopic imaging techniques (confocal, two-photon, TIRF) using knockout and transgenic mouse models and cell culture systems.
Anfangsdatum: 1. Januar 2018
Geschätzte Dauer: 3 Jahre
Bezahlung: 50% TV-L E13
Papers: Relevant papers can be found on our webpage: http://www.molcell.rwth-aachen.de/index.php/research/74-antigen-presenting-dendritic-cells
Sonstiges: We particularly welcome and encourage applications from women, disabled people and ethnic minority groups, recognizing they are underrepresented across RWTH Aachen University. The principles of fair and open competition apply and appointments will be made on merit.

Your application should include a cover letter, CV, academic transcripts and a list of potential referees. Please submit your full application preferentially as a PDF-file by e-mail (thieronymus@ukaachen.de) until November 5th, 2017.

We are looking forward to your application!

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