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Archiv-Übersicht     Angebot Nr. 12551

Angebotsdatum: 22. November 2017
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Sonstiges
Titel des Themas: Three positions for PhD/Early Stage Researchers, CaReSyAn Project, Marie Sklodowska-Curie ITN European Training Network, Europe

Institut: Institute for Molecular Cardiovascular Research (IMCAR)
Adresse:
Dr. rer. nat. Heidi Noels
Pauwelsstrasse 30
52074 Aachen
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
Homepage: http://www.imcar.rwth-aachen.de/
E-Mail Kontakt: mail

Beschreibung: CaReSyAn - Combatting the CardioRenal Syndrome: towards an integrative Analysis to reduce cardiovascular burden in chronic kidney disease
Would you like to do research on the increased cardiovascular risk in patients with chronic kidney disease? Would you like to increase your current knowledge on pathological mechanisms underlying the cardiorenal syndrome and contribute to the development of novel strategies to tackle this disease? Would you like to be part of a European PhD training network of leading universities and companies within Europe to boost your network?
Successfully combatting a complex disease requires multi-disciplinary and methodically well-trained scientists. CaReSyAn strives to accomplish exactly this: we will train 11 early-stage researchers to successfully integrate proteomics, clinical, experimental and bioinformatical analyses to enhance the understanding, diagnosis and therapy of the cardiorenal syndrome (CRS). CRS comprises disorders of the heart, vessels and kidneys, including the increased development of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). With ~45% of all deaths in CKD patients caused by CVD, the socio-economic burden of CRS is extremely high.
CaReSyAn will train 11 early-stage scientists in a close cooperation between academia, SME and industry partners within Europe. Key objectives are to provide:
1) Excellent scientific training on CRS pathology, integrating clinical/mechanistic knowledge with technological skills (animals and in vitro, molecular and functional studies, proteomics and bioinformatics) to generate innovative insights triggering the understanding, diagnosis and treatment of the CRS;
2) Excellent complementary skills in personal and career development as well as business training required to extend beyond scientific research; and
3) Exposure to both academic and non-academic environments, required to build bridges between researchers and entrepreneurs and support the future translation of research findings in innovative products and services.
CaReSyAn will nurture the development of young, broadly-trained scientists able to successfully bridge clinical with basic research as well as academia and industry. This is a cornerstone in effectively combatting complex diseases as CRS, a major killer of this century.

For more information on CaReSyAn: http://cordis.europa.eu/project/rcn/211577_en.html


Our profile
CaReSyAn is coordinated by our Institute for Molecular Cardiovascular Research (IMCAR), located at the University Hospital of the RWTH Aachen, Germany. We are committed to pursue scientific excellence in the field of cardiovascular biology. Our institute harbors a great expertise in a wide range of experimental methods and (animal) models related to cardiovascular research and is involved in many national as well as international research projects and networks.
Within IMCAR, Dr. Heidi Noels is leading the research group “Experimental cardiovascular pathology”, which uses a wide range of cellular and molecular biology methods combined with animal models to unravel the pathology underlying cardiovascular disease. Prof. Joachim Jankowski and Dr. Vera Jankowski are leading the proteomics unit in IMCAR, aiming at the identification of novel pathological mediators of cardiovascular disease.
Prof. Jürgen Floege is leading the Nephrology Department in the University Hospital of the RWTH Aachen and has a vast expertise in pathological calcification.
For more information, see http://www.imcar.rwth-aachen.de/


The projects
The PhD students will be enrolled in an intensive training program enrolled in a local PhD programme at the Medical Faculty of the RWTH Aachen, while at the same time being part of an integrated research team and research project at European network level. The 3 open PhD positions aim at obtaining a double degree (PhD and Dr. rer.nat.) from the RWTH Aachen University (Germany) and the Maastricht University (the Netherlands). The candidates will mainly work in the IMCAR institute in Aachen. Both projects include secondments within the CaReSyAn network.

Project 1: Effect of uremia on cardiac pathology: Given the increased cardiovascular risk in CKD patients, the PhD student will examine the direct effect of CKD and uremia on cardiomyocytes using a range of cellular biology techniques as well as animal studies. The project will reveal novel mediators negatively affecting cardiomyocyte function, enabling novel strategies to reduce cardiovascular risk in CKD patients (supervisor: Dr. H. Noels).

Project 2: Plasma peptidomics for the identification of CRS biomarkers: Based on our vast peptidomics experience to identify disease mediators, the PhD student will identify diagnostic and predictive biomarkers for the CRS in plasma using LC-MS/MS (supervisor: Prof. J. Jankowski).

Project 3: Vascular calcification in CRS. CKD patients show increased vascular calcification, highly increasing their risk of cardiovascular disease. Based on our extensive expertise in examining pathological calcification, the PhD student will examine novel mechanisms underlying increased vascular calcification in CKD using cellular biology techniques as well as animal studies (supervisor: Prof. J. Floege).
Methoden:
Anfangsdatum: 1. August 2018
Geschätzte Dauer: 3 years
Bezahlung:
Papers:
Sonstiges: Your profile:
- University degree in biology, biomedicine, biotechnology or natural sciences, biochemistry or comparable
- Interest in cardiorenal and cardiovascular research
- Good command of spoken and written English
- Experience in the field of cell culture, cellular biology and animal experiments are particularly desirable
- Above average motivation, teamwork and independency


According to the EU rules for the ITN projects, the recruited researchers must comply with the following conditions:
- are — at the date of recruitment — early-stage researchers (i.e. NOT have a doctoral degree AND be in the first 4 years (full-time equivalent research experience) of their research career)
- must comply with the following mobility rule: not have resided in the country of the recruiting beneficiary for more than 12 months in the 3 years immediately before the recruitment date (and not have carried out their main activity (work, studies, etc.) in that country) — unless as part of a procedure for obtaining refugee status under the Geneva Convention.

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