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Archiv-Übersicht     Angebot Nr. 12556

Angebotsdatum: 15. November 2017
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Biochemie
Titel des Themas: PhD student (E13/65%) in molecular Virology

Institut: Institute for Biochemistry
Prof. Lienhard Dr. Schmitz
Friedrichstrasse 24
35392 Giessen
Tel.: 0641-99-47570/1   Fax.:
Bundesland: Hessen
Homepage: http://https://www.uni-giessen.de/fbz/fb11/institute/biochemie/forschungbiochemie/agschmitz
E-Mail Kontakt: mail

Beschreibung: The Institute of Biochemistry (Medical Faculty) is inviting applications for a

PhD student (E13/65%) in molecular Virology

for the project "Phosphorylation-dependent signaling networks in influenza A virus-infected cells" This project is part of the SFB1021 and will be conducted in close collaboration with the group of Prof. Stephan Pleschka (Institute of Virology). The position is immediately available for initially 3 years.

The project:
The genomic plasticity of influenza A viruses (IAVs) enables the quick adaptation to new environments and crossing of species barriers which can cause occasional pandemics. We have investigated time-dependent changes in the phosphoproteomes of murine lung epithelial cells after infection with IAVs and identified hundreds of IAV-regulated phosphorylation events. The bioinformatic analysis of these modifications allowed the identification of many new IAV-regulated kinases. The role of these kinases for IAV infection is explored by gain-of-function and also loss-of-function experiments. In parallel, we will analyze the functional relevance of phosphorylations occuring on viral proteins. This is done by reverse genetics where phosphorylation sites are mutated and recombinant viruses are generated using eight plasmids encoding the viral RNAs. These experiments will allow to detect modifications that assist or antagonize viral replication. This demanding project involves a large spectrum of different methods from biochemistry, molecular biology and virology.

Your profile:
You have succesfully finished your Master or equivalent degree. You are highly self-motivated and ambitious and can work well in a highly active international research team, but also work on your own. Participation in the running teaching program is expected.

We offer:
The Institute (http://www.uni-giessen.de/cms/fbz/fb11/institute/biochemie/forschungbiochemie/agschmitz) offers the opportunity to work in an interactive and dynamic setting, is equipped with state-of-the-art facilities and well funded. We provide a creative working atmosphere and have active exchange programs with many scientists abroad.
Methoden: This demanding project involves a large spectrum of different methods from biochemistry, molecular biology and virology.
Anfangsdatum: 15. November 2017
Geschätzte Dauer: 3 years
Bezahlung: E13 / 65%
Papers: https://www.ncbi.nlm.nih.gov/pubmed/?term=schmitz+ml+Not+rock+Not+children+Not+aarhus+Or+Lienhard+Schmitz
Sonstiges: The university is an equal opportunity employer, and applications from women or candidates with children are encouraged. Applications of severely disabled with same suitability are preferred. Application deadline is 07.12.2017.

Please send your CV, two names of reference and the further usual documents via e-mail to

Prof. M.L. Schmitz
Biochemical Institute
Friedrichstrasse 24
35392 Giessen (Germany)
e-Mail: lienhard.schmitz@biochemie.med.uni-giessen.de

We would appreciate to receive the application via e-mail; if in paper only in copy, since we are not going to send your papers back after termination of the application procedure.