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Archiv-Übersicht     Angebot Nr. 12605

Angebotsdatum: 22. Dezember 2017
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Sonstiges
Titel des Themas: Increased cardiovascular risk in patients with chronic kidney disease

Institut: RWTH Aachen University/ Saarland University – Campus Homburg
Frau Heidi Noels
Pauwelsstrasse 30
52074 Aachen
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
E-Mail Kontakt: mail

Beschreibung: 6 Phd positions (m/f) Biology, Biotechnology, Biochemistry, Bioinformatics, Pharmaceutis or Molecular Medicine
in the framework of the DFG/SFB TRR219 Consortium “Mechanisms of Cardiovascular Complications in Chronic Kidney Disease” and associated projects
Funding is initially available for three years as a part time position (25,03 h/w), with the salary corresponding to level TV-L 13 and according to the German “Wissenschaftszeitvertragsgesetz” [WissZeitVG]. The successful candidate has the opportunity to pursue a doctoral degree.
Patients with chronic kidney disease (CKD) exhibit a massively increased risk for cardiovascular events: cardiovascular mortality accounts for ~40-50% of all deaths in patients with CKD stage 4/5, compared with 26% in controls with normal kidney function. In addition to the high risk for fatal atherosclerosis-related complications such as ischemic heart disease and stroke, cardiac deaths also result from heart failure and arrhythmias. CKD itself is an independent risk factor for cardiovascular events, and the underlying pathophysiological processes of cardiovascular disease (CVD) in CKD patients differ from the CVD processes in the general population. This may explain at least in part why traditional strategies to improve cardiovascular outcome have largely failed in the context of CKD. Also, it emphasizes the need to identify pathological mechanisms adversely affecting the cardiovascular system in CKD, with the aim to reduce the increased cardiovascular mortality in CKD patients through novel therapeutic strategies. Therefore, the aim of this Transregional Collaborative Research Center TRR219 is to analyze in experimental studies (in vitro, animal studies) and clinical studies the multi-factorial aspects of CKD-related cardiovascular morbidity and mortality caused by alterations in the circulation, the vessels as well as the myocardium. The projects:
Project 1: Metabolic and mitochondrial dysregulation in uremic cardiomyopathy: This project will examine the metabolic and mitochondrial dysregulation relevant for uremic cardiomyopathy. (PI: Dr. M. Lehrke, Cardiology, RWTH University Aachen).
Project 2: Role of interleukin-1α in CKD-associated cardiovascular complications: This project will analyze the role and biogenesis of the proinflammatory cytokine Interleukin-1α in CKD with methods entailing high resolution microscopy, molecular biology, biochemistry parallel to physiological as well as clinical read-outs of cytokine signaling. (PIs: Prof. B. Niemeyer, Institute of Biophysics; Dr. med. S. Zewinger, Nephrology; Saarland University – Campus Homburg).
Project 3: PDGF - a mediator of CVD in CKD: In this project we will analyze the role of Platelet-derived Growth Factor (PDGF) in the pathogenesis of cardiovascular disease in CKD using a wide range of animal transgenic models and tools, in vitro experiments, and particularly cutting edge imaging technologies (PI Dr. P. Boor, Pathology; RWTH University Aachen).
Project 4: Mass spectrometry to identify novel regulators of pathological processes underlying CKD-associated CVD: This project will use MALDI mass spectrometry and chromatographic separation to identify novel mediators of pathological processes as well as to identify post-translational modifications of proteins and peptides in the context of CKDassociated CVD (PI Dr. V. Jankowski, Institute for Molecular Cardiovascular Research; RWTH University Aachen).
Project 5+6: Mass spectrometry to identify biomarkers and mediators in chronic renal failure (P5) and CVD (P6): This project will use mass spectrometry (e.g. electron-spray ionization MS) and system biology as a state-of-the-art methods to identify novel biomarkers and mediators in plasma of patients suffering from chronic renal failure (in project 5) and cardiovascular diseases (in project 6) as well as animal models (PI Prof. J. Jankowski, Institute for Molecular Cardiovascular Research; RWTH University Aachen). Your profile:
highly motivated students (m/f) holding a Master degree or equivalent in Biology, Biotechnology, Biochemistry, Bioinformatics, Pharmaceutics or Molecular Medicine, preferably with experimental research experience strong interest in pathology, immunology, cellular and molecular biology and/or mass spectrometry strong motivation to work in a competitive research environment good English language proficiency (spoken and written) for project 1 and 3 – experience in animal handling is an advantage Our profile:
The participating research groups are from preclinical and clinical disciplines in cardiology, nephrology and pathology. They are located at the academic hospital of the RWTH Aachen University or the Saarland University – Campus Homburg, as indicated in the respective project descriptions.
The RWTH Aachen University has more than 40,000 students and almost 6000 academic staff members, representing one of the largest universities in Germany. Saarland University – Campus Homburg harbours the Faculty of Medicine of
Saarland University. The medical center of Saarland University is composed of 30 clinics and 20 institutes, and represents a large educational center in Germany, with around 2,000 students being trained annually in human and dental medicine, human and molecular biology and bioinformatics.
We offer:
Enrolment in the PhD graduate school as integral part of our DFG/SFB 219 Consortium as well as within the local PhD programs at the respective universities, offering an intensive and dedicated PhD training program a highly dynamic research environment in an interdisciplinary clinical and basic research setting with state-of-theart laboratory equipment intensive cooperations within the DFG/SFB TRR219 Consortium
To apply:
Interested candidates should send their application (code-no: GB-P-8112) including a current curriculum vitae, motivation letter, academic transcripts, 3 recommendation letters and indication of three projects of preference by January 31st, 2018 to: TRR219jobs@gmail.com.
For further information please contact: Mrs. Sandra Knarren, Institute for Molecular Cardiovascular Research, University Clinic RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany,Tel: +49 241 80 80580.
The RWTH Aachen University and Saarland University are certified as family-friendly universities. We particularly welcome and encourage applications from women, disabled people and ethnic minority groups, recognizing they are underrepresented across our Universities. The principles of fair and open competition apply.
Anfangsdatum: 31. Januar 2018
Geschätzte Dauer: 3 years