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Archiv-Übersicht     Angebot Nr. 12607

Angebotsdatum: 29. Dezember 2017
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Anthropologie
Titel des Themas: PhD Student in Cardiovascular Research - 3 year fixed-term contract (up to 4 years), full time, starting early 2018

Institut: Luxembourg Institute of Health
Frau Christelle christelle.massaux@lih.lu
1A Rue Thomas Edison
1445 Strassen - Luxembourg
Tel.:    Fax.:
Homepage: http://https://www.lih.lu/jobs/detail/phd-student-in-cardiovascular-research-yd1217-12713
E-Mail Kontakt: mail

Beschreibung: Luxembourg Institute of Health is a public research organisation at the forefront of biomedical sciences. With its strong research expertise in oncology, population health, infection and immunity based on human biological samples, its research activities impact on people’s health. At the Luxembourg Institute of Health, devoted scientists investigate disease mechanisms to develop new diagnostics, innovative therapies and effective tools to implement personalised medicine. The institution is the first supplier of public health information in Luxembourg, a strong cooperation partner in local and international projects and an attractive training place for ambitious early-stage researchers.

In the context of a FNR-funded CORE project, Dr Yvan Devaux (Head of Cardiovascular Research Unit) is looking to recruit a :

PhD Student in Cardiovascular Research
3 year fixed-term contract (up to 4 years), full time, starting early 2018

PhD Student in Cardiovascular Research
3 year fixed-term contract (up to 4 years), full time, starting early 2018

The project aims to identify novel RNA biomarkers that can be used to predict neurological outcome and survival after
cardiac arrest. Cardiac arrest is a main health issue affecting 400,000 persons per year in Europe and 400 in Luxembourg.

Despite modern health care strategies, half of patients successfully resuscitated from out of hospital cardiac arrest suffer severe and irreversible damage of the brain and die within few days. Even though the need for a personalized healthcare system is recognized, personalized medicine is still far from being widely implemented. In the context of cardiac arrest, the implementation of personalized healthcare is limited by a lack of specific prognostication strategies. The present
project aims to tackle this unmet clinical need and will focus on the discovery and validation of novel RNA biomarkers.
Past investigations from the Cardiovascular Research Unit allowed to identify microRNAs in cardiac arrest patients (PMIDs 22890253; 25886727; 27438111; 28819446; 29159560). Here, the aim is to extend these research activities to the longer arm of the non-coding RNA family, i.e. long non-coding RNAs and circular RNAs.
Methodologies will include deep RNA sequencing, quantitative PCR, molecular biology, biochemistry, bioinformatics and biostatistics. One national and two international multicenter cohorts of patients with cardiac arrest are available for the project.

More information about the Unit can be found here :


Purpose of the position:
- Participate in the setting-up of a research project.
- Carry out and finalize a research project by writing a PhD thesis in the view of obtaining a PhD degree.
- Publish her/his results in scientific journals and/or file patents if applicable.
- Disseminate her/his results to the scientific community and the general public.

Key Skills, Experience and Qualifications:
- Master’s degree (or equivalent), preferably in biomedical sciences.
- Basic knowledge of molecular biology, cardiovascular pathology, bioinformatics, and/or biostatistics is required.
- Excellent time management, rigor, perseverance, scientific creativity and originality, writing skills, conciseness,
sense of priority and ability to work with others.
- IT skills: Office, Outlook, Endnote.
- Languages skills: fluent command of English, knowledge of another language of the European Union (e.g. french) is an asset.

Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with the university and other research institutes.
Methoden: Located in Luxembourg, LIH offers the opportunity to work in a dynamic, international and multilingual environment that values personal respect and professional achievement based on the highest intellectual and ethical standards.
Anfangsdatum: 1. Februar 2017
Geschätzte Dauer: 3 year fixed-term contract (up to 4 years), full t