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Archiv-Übersicht     Angebot Nr. 12622

Angebotsdatum: 9. Januar 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Physiologie
Titel des Themas: Redox changes during onset of metabolic diseases

Institut: Universität des Saarlandes
Prof. Leticia Prates Roma
Kirrberger str Gebäude 48
66421 Homburg
Tel.: +49068411616240   Fax.:
Bundesland: Saarland
E-Mail Kontakt: mail

Beschreibung: A PhD student position is available in the Department of Biophysics, Zentrum für Human- und Molekularbiologie at Saarland University (Homburg- Germany), to study the causal relationship between redox changes and diabetes onset. In this project we will make use of animal models stably expressing novel genetically encoded redox biosensors to gain deeper understanding of the role of defined redox species in pancreatic beta cell failure and function during diabetes development.

We are looking for a highly motivated and ambitious student holding a Masters degree in the areas of Molecular Medicine, Biophysics, Biology, Biochemistry, Physiology, Pharmacology or closely related fields. We expect excellent oral and written communication skills in English and an ability to work both in a group and independently.

The successful applicant will be part of the interdisciplinary cell biological research environment of the Center for Integrative Physiology and Molecular Medicine which is located in a brand-new research building.

Homburg is located close to the famous Palatinate forest, with a very affordable cost of living. Transport links are good with both Paris and Frankfurt less than 2 hours away by train.

Interested applicants should send a cover letter, a copy of their CV, transcripts of Bachelor and master degrees, as well as two contactable references as a PDF file to: leticia.prates-roma@uks.eu

For further information please contact
Jun. -Prof. Dr. Leticia Prates Roma
CIPMM - Biophysics Department
Zentrum für Human- und Molekularbiologie - Universität des Saarlandes
66421 Homburg/Saar, Germany
e-mail: leticia.prates-roma@uks.eu
Anfangsdatum: 9. Januar 2018
Geschätzte Dauer: 36 months
Bezahlung: Fully funded. E13-50%
Papers: Roma LP*, Deponte M, Riemer J, Morgan B. Mechanisms and applications of redoxsensitive
GFP-based H2O2 probes. Antioxid Redox Signal. 2017 Nov 21. doi:
10.1089/ars.2017.7449. *shared corresponding author

2.Fujikawa Y* & Roma LP*, Sobotta MC, Rose AJ, Diaz MB, Locatelli G, Breckwoldt M,
Misgeld T, Kerchensteimer M, Herzig S, Muller-Decker K, Dick TP. Mouse redox
histology using genetically encoded biosensors. Science Signaling. 2016 Mar
15;9(419):rs1. doi: 10.1126/scisignal.aad3895.*shared first author

3. Cabezas-Wallscheid N, Buettner F, Klimmeck D, Sommerkamp P, Ladel L, Thalheimer
FB, Pastor-Flores D, Roma LP, Renders S, Scognamiglio R, Zeisberger P, Przybylla A,
Altamura S, Florian CM, Fawaz M, Vonficht D, Collier P, Pavlinik D, Geiger H, Schroeder
T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A. Vitamin A-Retinoic Acid Signaling
Regulates Hematopoietic Stem Cell Dormancy. Cell. 2017 May 18;169(5):807-823.e19.
doi: 10.1016/j.cell.2017.04.018.