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Archiv-Übersicht     Angebot Nr. 12626

Angebotsdatum: 11. Januar 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Neurobiologie
Titel des Themas: RTG1715-Project: Temporal and spatial analyses of signalling cues in the membranes of postsynaptic spines during synaptic plasticity

Institut: Institute for Biochemistry I, Jena University Hospital – Friedrich Schiller University Jena
Adresse:
Herr Michael Kessels
Nonnenplan 2-4
07743 Jena
Tel.:    Fax.:
Bundesland: Thüringen
Homepage: http://www.biochemie.uniklinikum-jena.de/en/Biochemistry+I.html
E-Mail Kontakt: mail

Beschreibung: 1 PhD position in Neurobiology / Cell biology / Imaging / Biochemistry

RTG1715-Project:
Temporal and spatial analyses of signalling cues in the membranes of postsynaptic spines during synaptic plasticity
Michael Kessels lab

We seek for a productive addition to our team. Applicants should have solid theoretical and practical knowledge of cell/neurobiology, biochemistry, molecular biology and/or imaging techniques. Candidates need to be distinguished by high motivation to succeed in science and by being kind, efficient and reliable team-players able to integrate into our international team smoothly.
Knowledge of the german language is not required because of the internationality of our group, of the research training group (RTG; "Graduiertenkolleg") and of the lively university town of Jena. Fluent English, however, is a prerequisite.

The institute provides a stimulating, international research environment with excellent technical equipment right in the centre of Jena.

The aim of our internationally well-known research team is to gain a molecular understanding of how the topologies and shapes of the plasma membrane, cellular compartments and entire cells that are required for their biological functions are brought about and how such membrane shaping processes contribute to development, plasticity and function of cells and cellular networks, such as those formed by neurons in the brain.
Please feel free to check out some examples of first-author papers of PhD students in the lab for getting an overview over topic and methods we apply (please see literature below).

The RTG: The RTG1715 offers a structured supervision complemented by a training program. Each doctoral candidate will work in an interdisciplinary research
project and will be jointly supervised by a main supervisor and two further investigators with complementary expertise (thesis committee). The group of positions offered corresponds to the 3rd generation of students within the RTG. The project headed by M. Kessels is in the good position of having the generation 2 student still in the lab. This will ensure a smooth start of the generation 3 project.

The project: The project aims at doing quantitative spatio-temporal analyses of signals at the plasma membrane of postsynaptic spines of excitatory hippocampal neurons during NMDA-induced long-term depression (LTD) - a synaptic plasticity process thought to underlie learning and memory processes.
Preliminary results to be built on and expanded suggest that signalling is organized in form of nanodomains and follows a dynamic biphasic PIP2 response in specifically the postsynaptic scaffold-containing spine heads (MacKenzie; unpublished).
Methoden: quantitative spatio-temporal analyses of signals at the plasma membrane of postsynaptic spines of excitatory hippocampal neurons during NMDA-induced long-term depression (LTD)
Anfangsdatum: 1. April 2018
Geschätzte Dauer: 3 Years; The position is funded by the Deutsche Fo
Bezahlung: 50 and 65% respectively of state salary E13 (postd
Papers: Braun et al. 2005 Mol. Biol. Cell; Ahuja et al. 2007 Cell; Dharmalingam et al. 2009 J. Neurosci.; Koch (D) et al. 2011 EMBO J.; Schwintzer et al. 2011 EMBO J.; Koch (N) et al. 2012 J. Cell Sci.; Schneider et al., 2014 J. Cell Biol.; Hou et al., 2015 PLoS Biology; Seemann et al., Dec. 2017 eLIFE; Izadi et al., 2018 J. Cell Biol.
Sonstiges: Please direct your complete application (coverletter;CV; certificates incl. grades and grading explanation, if necessary; list of publications honours etc., if any; 2-3 ref. addresses) to

Priv. Doz. Dr. Michael M. Kessels
Institute of Biochemistry I,
Jena University Hospital - Friedrich Schiller University Jena
Nonnenplan 2-4, D-07743 Jena
Germany

Please submit your application by E-mail to
Michael.Kessels@med.uni-jena.de
(PDFs strongly preferred)


The FSU Jena is an equal opportunity employer promoting the advance of women in science.

Jena is ranked second in the German career atlas (right behind Munich)!

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