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Archiv-Übersicht     Angebot Nr. 12628

Angebotsdatum: 11. Januar 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: 1 PhD position in an internationally known lab (Qualmann/Kessels labs) in Cell biology / Biochemistry / Signaling -- RTG1715-Project: Signaling pathways controlling actin dynamics in adaptive stress responses in the brain

Institut: Institute for Biochemistry I, Jena University Hospital – Friedrich Schiller University Jena
Adresse:
Herr Michael Kessels
Nonnenplan 2-4
07743 Jena
Tel.:    Fax.:
Bundesland: Thüringen
Homepage: http://www.biochemie.uniklinikum-jena.de/en/Biochemistry+I.html
E-Mail Kontakt: mail

Beschreibung: 1 PhD position in an internationally known lab (Qualmann/Kessels labs) in Cell biology / Biochemistry / Signaling

RTG1715-Project:
Signaling pathways controlling actin dynamics in adaptive stress responses in the brain
Britta Qualmann
Institute for Biochemistry I, Jena University Hospital – Friedrich Schiller University Jena

We seek for a productive addition to our team. Applicants should have solid theoretical and practical knowledge of cell/neurobiology, biochemistry, molecular biology and/or imaging techniques. Candidates need to be distinguished by high motivation to succeed in science and by being kind, efficient and reliable team-players able to integrate into our international team smoothly.
Knowledge of the german language is not required because of the internationality of our group, of the research training group (RTG; "Graduiertenkolleg") and of the lively university town of Jena. Fluent English, however, is a prerequisite.

The institute provides a stimulating, international research environment with excellent technical equipment right in the centre of Jena.

The aim of our internationally well-known research team is to gain a molecular understanding of how the topologies and shapes of the plasma membrane, cellular compartments and entire cells that are required for their biological functions are brought about and how such membrane shaping processes contribute to development, plasticity and function of cells and cellular networks, such as those formed by neurons in the brain.
Please feel free to check out some examples of first-author papers of PhD students in the lab for getting an overview over topic and methods we apply

The RTG: The RTG1715 offers a structured supervision complemented by a training program. Each doctoral candidate will work in an interdisciplinary research
project and will be jointly supervised by a main supervisor and two further investigators with complementary expertise (thesis committee). The group of positions offered corresponds to the 3rd generation of students within the RTG. The project headed by B. Qualmann is in the good position of having the generation 2 student still in the lab. This will ensure a smooth start of the generation 3 project.

The project: Adaptive responses in neurons require morphological alterations in cell shape that are controlled by the cortical actin cytoskeleton. The proposed project is built on the identification and initial characterization of the actin nucleator Cobl as being critical for neuromorphogenesis and regulated by Ca2+/CaM (Ahuja et al., 2007 Cell; Hou et al., 2015 PLoS Biol). The project focusses on revealing molecular mechanism that may regulate important functional and mechanistic aspects of Cobl functions in the development and plastic rearrangement of the dendritic arbor of neurons. The identification of Cobl as phospho-protein in several phosphoproteomic screens suggested that, in addition to Ca2+/CaM signaling, posttranslational modifications may control the potent actin nucleator Cobl. We will unveil the role of Cobl phosphorylation sites in neuronal network formation and plasticity by the use of Cobl mutants mimicking both the phosphorylated and the non-phosphorylated state in both gain-of-function studies and in rescue experiments of Cobl loss-of-function. Furthermore, the kinases and phosphatases involved will be identified in both biochemical as well as cell biological studies by applying the respective inhibitors.
This work shall subsequently allow us to investigate the effects of Ca2+-mediated signaling on cytoskeletal-driven structural and functional adaptive responses in neurons under physiological as well as excitotoxic conditions in a dose- and time-course dependent manner and unveil the exact signaling cascades involved and their temporal coordination during adaptive stress responses in dendritic arborization as well as synapse formation and plasticity.
Methoden: unveil the role of Cobl phosphorylation sites in neuronal network formation and plasticity by the use of Cobl mutants mimicking both the phosphorylated and the non-phosphorylated state in both gain-of-function studies using neuronal cultures ((confocal) fluorescence microscopy).
Rescue experiments of Cobl loss-of-function.
Protein biochemical mechanistic studies.
Identify the kinases and phosphatases involved in both biochemical as well as cell biological studies (use of inhibitors).
Anfangsdatum: 1. April 2018
Geschätzte Dauer: 3 Years; The position is funded by the Deutsche Fo
Bezahlung: 50 and 65% respectively of state salary E13 (postd
Papers: Braun et al. 2005 Mol. Biol. Cell; Ahuja et al. 2007 Cell; Dharmalingam et al. 2009 J. Neurosci.; Koch (D) et al. 2011 EMBO J.; Schwintzer et al. 2011 EMBO J.; Koch (N) et al. 2012 J. Cell Sci.; Schneider et al., 2014 J. Cell Biol.; Hou et al., 2015 PLoS Biology; Seemann et al., 2017 eLIFE; Izadi et al., 2018 J. Cell Biol..
Sonstiges: Please direct your complete application (coverletter;CV; certificates incl. grades and grading explanation, if necessary; list of publications honours etc., if any; 2-3 ref. addresses) to

Prof. Dr. Britta Qualmann
Institute of Biochemistry I,
Jena University Hospital - Friedrich Schiller University Jena
Nonnenplan 2-4, D-07743 Jena
Germany

Please submit your application by E-mail to
Michael.Kessels@med.uni-jena.de
(PDFs strongly preferred)

The FSU Jena is an equal opportunity employer promoting the advance of women in science.

Jena is ranked second in the German career atlas (right behind Munich)!
(http://www.karriere.de/beruf/muenchen-jena-berlin-die-top-regionen-in-deutschland-7952/)
"That Jena scores so well is the result of a successful combination of research, education and economics."
"University: 25% of all inhabitants are students and Jena thus is a very young and lively city. The job market is hot."
"Jena is well-known as internationally leading place for optics. Companies, such as Carl Zeiss, Jenoptik and Schott set global standards."

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