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Archiv-Übersicht     Angebot Nr. 12629

Angebotsdatum: 5. Juli 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Physik > Theoretische Physik
Titel des Themas: Computational study of biofabrication for artificial tissue generation

Institut: Biofluid Simulation and Modeling
Prof. Stephan Gekle
Universitätsstr. 30
95445 Bayreuth
Tel.: 0921 55 4462   Fax.:
Bundesland: Bayern
Homepage: http://biofluid.physik.uni-bayreuth.de
E-Mail Kontakt: mail

Beschreibung: Biofabrication, the 3D printing of living cells, is a fascinating new approach to produce living artificial tissue and to overcome the shortage of donor organs in hospitals. Currently, however, the widespread use of this technology is prevented by a number of problems. The most severe of these is the high percentage of cells being killed or damaged by mechanical stresses during print-ing. The SFB/TRR 225 at the Universities of Würzburg and Bayreuth addresses this problem in a joint effort by around 20 research groups from chemistry, biology, medicine and physics.

The current project is part of this effort and aims to develop a computational scheme which al-lows efficient and accurate computer simulations of biofabrication. Using this novel tool and in collaboration with our experimental colleagues we will thrive to understand the physical origin of mechanical cell damage and its biological consequences. Based on these insights we will finally develop new techniques to enable the biofabrication of living cells with nearly 100% survival rate.

Simulations will be run using the ESPResSo simulation package which will need to be extended by the prospective candidate. Analysis tools will be written by the candidate in C/C++. The required supercomputer ressources will be provided by the local computing cluster available at the Uni-versity of Bayreuth as well as by projects on national supercomputing systems such as SuperMUC and JURECA.

The successful candidate must possess a strong background in theoretical physics, numerical mathematics, computational engineering or a similar discipline. Interest in writing and using computer codes (C/C++) is required. A background in fluid mechanics or biology is desirable, but not explicitly required. Research will be conducted in the Biofluid Simulation and Modelling group at the University of Bayreuth, Germany. Bayreuth is a medium-sized town with a large stu-dent population and is situated in a beautiful natural setting between the mountains of the "Fränkische Schweiz" and "Fichtelgebirge".

For applications or further information please contact: Stephan Gekle, stephan.gekle@uni-bayreuth.de, or see our website biofluid.physik.uni-bayreuth.de
Methoden: Computersimulationen
Anfangsdatum: 5. Juli 2018
Geschätzte Dauer: 3 Jahre
Bezahlung: TVL 13