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Archiv-Übersicht     Angebot Nr. 12658

Angebotsdatum: 30. Januar 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: Principles of Chitin Immune Recognition and Signaling

Institut: Interfakultäres Institute für Zellbiologie, Abteilung Immunologie
Adresse:
Prof. Alexander Weber
Auf der Morgenstelle 15
72076 Tübingen
Tel.: 07071 2987623   Fax.:
Bundesland: Baden-Württemberg
Homepage: http://www.immunology-tuebingen.de/groups/alexander-nr-weber.html?Fsize=%2Fproc%2Fself%2Fgroups%2Fralf-amann%2Fpublications.html
E-Mail Kontakt: mail

Beschreibung: Topic | The innate immune systems in plants and humans rely on the recognition of microbes through conserved molecular patterns by so-called pattern recognition receptors (PRRs). However, the human PRR for chitin, a medically relevant, abundant polysaccharide found in insects and fungi and in humans associated with multiple diseases, remains unknown. Using biochemical, immunological and cellular methodologies, our lab aims to dissect principles of chitin recognition in mammals by using a multi-faceted, collaborative, interdisciplinary and interfaculty approach to obtain insights into principles of pathogen recognition and innate immunity. Specifically, we would like to understand how a candidate receptor we identified binds and responds to chitin oligomers, which co-receptors are involved and how this relates to anti-fungal responses in vitro and in vivo.

Suggested reading | Kawai & Akira. Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity. Immunity 2011. Lee, Da Silva, Lee, Hartl & Elias. Chitin regulation of immune responses: an old molecule with new roles. Curr Opin Immunol 2008.
Methoden: Methods | Standard molecular biology (PCR, restriction digests, sub-cloning), reporter signaling assays, analyses in human primary immune cells (phospho-flow cytometry, intracellular cytokine stain), protein-protein and protein-ligand interaction assays, phospho-proteomics, protein expression and purification.
Anfangsdatum: 1. März 2018
Geschätzte Dauer: 3 Jahre
Bezahlung: TV-L E13 65%
Papers: Suggested reading | Kawai & Akira. Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity. Immunity 2011. Lee, Da Silva, Lee, Hartl & Elias. Chitin regulation of immune responses: an old molecule with new roles. Curr Opin Immunol 2008. Mack I, …, Weber A, Mall MA, Hartl D. The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases. Mol Cell Pediatr. 2015 Dec;2(1):3. doi: 10.1186/s40348-015-0014-6.
Sonstiges: Your profile | Masters degree or equivalent in biological sciences or medicine, and some research experience in molecular/cellular biology, microbiology/virology, protein biochemistry and/or immunology; high motivation to work independently and as part of a team; good command of the English language (written and spoken); both German and international applications encouraged.

Your application | Please send the following complete materials electronically to alexander.weber@uni-tuebingen.de: Cover/motivation letter (max 1 A4), CV, transcripts/certificate of diploma and bachelor degree, support letter from at least 1 previous supervisor. Applications will be reviewed on an ongoing basis.

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