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Archiv-Übersicht     Angebot Nr. 12674

Angebotsdatum: 7. Februar 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Pathologie
Titel des Themas: Cross-talk of the nuclear transport system and cancer-relevant signalling pathways.

Institut: Institut für Pathologie Universitätsmedizin Greifswald
Prof. Stephan Singer
Friedrich-Loeffler-Str. 23e
17475 Greifswald
Tel.:    Fax.:
Bundesland: Mecklenburg-Vorpommern
E-Mail Kontakt: mail

Beschreibung: The selective exchange of molecules between the nucleus and the cytoplasm is provided by the nuclear transport machinery. The nuclear transport system consists of a variety of nuclear transport receptors (e.g importins and exportins) shuttling cargos through the nuclear pore complex (NPC) composed of ~ 30 nucleoporins (Nups). We are focusing on the cross-talk between the nuclear transport system and (liver) cancer-relevant signalling pathways (e.g. p53 pathway).
Methoden: Elaborate cell culture systems, molecular/cell biology techniques, transcriptomics, proteomics, and tissue-related analyses (such as immunohistochemistry, immunofluoresence, NGS, tissue microarrays and tissue-based proteomics).

Anfangsdatum: 7. Februar 2018
Geschätzte Dauer: 3-4 Jahre
Bezahlung: E 13 Stufe 2
Papers: selected publications:
Beck M, Schirmacher P, Singer S. Alterations of the nuclear transport system in hepatocellular carcinoma - new basis for therapeutic strategies. (2017) J Hepatol 67:1051-1061

Buczak K,....Singer S* & Beck M* Spatial tissue proteomics quantifies inter- and intra-tumor heterogeneity in hepatocellular carcinoma. Mol Cell Proteomics [epub ahead of print]

Winkler J,....& Singer S (2014) Prosurvival function of the cellular apoptosis susceptibility/importin-alpha1 transport cycle is repressed by p53 in liver cancer. Hepatology 60: 884-95.

Singer S ...& Prives C (2012) Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. Molecular Cell 14;48:799-810
Sonstiges: We are looking for highly motivated and hard working candidates ideally holding a MSc in Biology, Biotechnology, Biochemistry or Molecular Medicine.