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Archiv-Übersicht     Angebot Nr. 12684

Angebotsdatum: 12. Februar 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Centrosome Duplication

Institut: Universität Heidelberg, Zentrum f. Molakulare Biologie
Adresse:
Prof. Elmar Schiebel
Im Neuenheimer Feld 282
69120 Heidelberg
Tel.:    Fax.:
Bundesland: Baden-Württemberg
Homepage:
E-Mail Kontakt: mail

Beschreibung: The centrosomes is the main microtubule organizing centre of human cells. As DNA centrosomes duplicate once per cell cycle. Malfunction of centrosome duplication is a hallmark of cancer cells and recent data suggest that centrosome overamplificaiton contributes to cell transformation. In addition, lack of centrosomes or to many centrosomes causes chromosome missegregation and p53 activation leading to cell cycle arrest in G1.

In this project we will study cell cycle dependent centrosome duplication and steps leading to centrosome maturation in G2 and mitosis. The PhD student will use biochemical approaches, super resolution microscopy (STED), electron microscopy, CRISPR/Cas9 technology and live cell imaging to study centrosome duplication in untransformed and cancer cells.
Methoden:
Anfangsdatum: 15. März 2018
Geschätzte Dauer: 3 years
Bezahlung: TV-L E13/60%
Papers: Relevant publications:

1-51 Mardin, B. R., Agircan, F. G., Lange, C. & Schiebel, E. Plk1 Controls the Nek2A-PP1gamma Antagonism in Centrosome Disjunction. Curr Biol 21, 1145-1151, doi:S0960-9822(11)00605-1 [pii]
10.1016/j.cub.2011.05.047 (2011).
2 Mardin, B. R. et al. EGF-induced centrosome separation promotes mitotic progression and cell survival. Dev Cell 25, 229-240, doi:S1534-5807(13)00161-5 [pii]
10.1016/j.devcel.2013.03.012 (2013).
3 Mardin, B. R. et al. Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat Cell Biol 12, 1166-1176, doi:ncb2120 [pii]
10.1038/ncb2120 (2010).
4 Mardin, B. R. & Schiebel, E. Breaking the ties that bind: New advances in centrosome biology. J Cell Biol 197, 11-18, doi:jcb.201108006 [pii]
10.1083/jcb.201108006 (2012).
5 Rüthnick, D. & Schiebel, E. Duplication of the yeast spindle pole body once per cell cycle. Mol Cell Biol 36, 1324-1331, doi:10.1128/MCB.00048-16 (2016).
Sonstiges: Highly motivated PhD students with a background in biochemistry, cell biology or molecular biology should apply. Successful candidates will be part of an international team of PhD students and postdocs that works at the forefront of scientific research. The PhD student will be a member of the Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (http://www.hbigs.uni-heidelberg.de/). The PhD position is funded for 3 years.

Please send applications to E. Schiebel (schiebel.elmar@zmbh.uni-heidelberg.de).

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