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Archiv-Übersicht     Angebot Nr. 12690

Angebotsdatum: 14. Februar 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Tiermedizin > Sonstiges
Titel des Themas: "Sperm morphology and motility in mice and men: Investigations of defective male germ cell differentiation"

Institut: JLU, Institute for Veterinary Anatomy, Histology and Embryology
Adresse:
Frau Pia Jürgens
Aulweg 123
35392 Giessen
Tel.: 0641 9947173   Fax.: 0641 9947189
Bundesland: Hessen
Homepage: http://www.uni-giessen.de/IRTG-monash-giessen
E-Mail Kontakt: mail

Beschreibung: Collaborative project P 1 (out of 11) of the International Research Training Group "Molecular Pathogenesis of Male Reproductive Disorders" between Monash University, Melbourne (AUS) and Justus Liebig University, Giessen (Germany)

The differentiation of male haploid germ cells to motile and mature sperm is the last, but essential step during spermatogenesis. Failure of these differentiation steps, e.g. shaping of the sperm head and formation of the flagellum leads to severely disturbed spermatogenesis, i.e. so-called oligoasthenoteratozoospermia (low sperm count, immotile and morphologically abnormal sperm) or even azoospermia (no sperm at all in the ejaculate) and therefore male infertility. Infertility causes in men are still mostly "idiopathic", so no distinct cause is known. During the three years of the project, the doctoral researcher will investigate the correlation between sperm morphology and motility and their disorders leading to impaired fertility in men and mice. Experiments will be conducted complementarily in Germany and Australia. Testicular biopsies and ejaculate samples of fertile and infertile men will be examined in Germany as a model for normal and impaired spermatogenesis and correlated to results generated by knockout mouse models in Australia. Histological and molecular biological methods as well as mass spectrometry on human ejaculates will be performed to assess sperm differentiation in health and disease.

Students in the IRTG are co-supervised by researchers in both universities, get specialized postgraduate training and carry out research in the laboratories at both sites, with the possibility to achieve a Joint Award (min. 12 months abroad).
Methoden: You have a high-ranked degree in biology or molecular biology. Your eligibility is not only reflected by your marks, but you demonstrate outstanding interest in scientific issues and show excellent analytical skills. You can document your scientific suitability by your own scientific work and e.g. voluntary internships and lab rotations. You are familiar with basic histological and molecular techniques. Knowledge of more sophisticated methods (e.g. mass spectrometry) is of advantage. You are keen on learning about new methodologies. You are a teamworker but also able to develop your own ideas independently and find solutions for open questions and challenges. You should be familiar with basics of data analysis, literature research and scientific writing.

Offering an international training scheme designed to develop and advance future leaders in men's health research, IRTG is looking for highly motivated, committed and persistent candidates showing excellent qualifications. A prerequisite for participation is a degree of top 15 % and a class rank of top 20%. A very good command of English (written and spoken) and of standard software is also mandatory.
Anfangsdatum: 14. Februar 2018
Geschätzte Dauer: 3 years
Bezahlung: first stipend, later employment E13, TV-H (65%)
Papers:
Sonstiges: We (Prof. Bergmann group) are a dynamic young team located at the Faculty of Veterinary Medicine. We have built up intense collaborations with the local Urological Clinic in Giessen and by this are able to combine both an easy access to testicular and ejaculate samples and a smooth processing of clinical samples in our labs. Moreover, we have close collaborations with all andrological core facilities in Germany. We can offer modern lab facilities, equiment and methodological expertise in a wide histological and molecular biological field. Beside working on a clearly defined project with intensive supervision, the student is fostered to bring in own ideas and work also independently within his or her project. By this, the doctoral student can develop in the exciting scientific field of reproductive medicine and is able to establish an own standing in the scientific community.

The Monash-JLU IRTG focuses on male reproductive health and medicine undertaken at basic and translational research centres in both Australia and Germany, capitalizing on the complementary strenghts at the two partner universities. It fosters an intellectural environment building local and international research capacity.

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