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Archiv-Übersicht     Angebot Nr. 12691

Angebotsdatum: 14. Februar 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Tiermedizin > Ambulatorische & Geburtshilfliche Tiermedizin
Titel des Themas: "Human testis cancer and spermatogenesis control by immune cells"

Institut: JLU, Institute for Veterinary Anatomy, Histology and Embryology
Frau Pia Jürgens
Aulweg 123
35392 Giessen
Tel.: 0641 9947173   Fax.: 0641 9947189
Bundesland: Hessen
Homepage: http://www.uni-giessen.de/IRTG-monash-giessen
E-Mail Kontakt: mail

Beschreibung: Collaborative project P2 (out of 11) of the International Research Training Group "Molecular Pathogenesis of Male Reproductive Disorders" between Monash University, Melbourne (AUS) and Justus Liebig University, Giessen (Germany)

Immune cells play an essential role in development and maintenance of human and mouse testis. So far it is not known, if and how an immune cell-shaped environment contributes to the development of testicular cancer as immune cell infiltrates are common in manifest testicular cancer (seminoma) and precancerous conditions (germ cell neoplasia in situ, GCNIS). The presence of immune cells such as macrophages and dendritic cells and respective subtypes is hypothesized to shape the testicular environment and support cancer cell development. Experiments will be conducted complementarily in Germany and Australia. At JLU, histological assessment of immune cells in human testis biopsies showing normal and impaired spermatogenesis, GCNIS and seminoma with or without lymphatic infiltrates will be performed to delineate the immune cell-germ cell dialogue. Using immunohistochemical and molecular biological techniques, immune cells subsets and soluble factors as chemo- and cytokines will identified. At Monash, these results will be complemented with cell culture experiments on human seminoma cells (TCAM-2). Special hypotheses will be addressed in mouse models.

Students in the IRTG are co-supervised by researchers in both universities, get specialized postgraduate training and carry out research in the laboratories at both sites, with the possibility to achieve a Joint Award (min. 12 months abroad).
Methoden: You have a high-ranked degree in veterinary medicine, medicine, biology or molecular biology. Your eligibility is not only reflected by your marks, but you demonstrate outstanding interest in scientific issues and show excellent analytical skills. You can document your scientific suitability by your own scientific work and e.g. voluntary internships and lab rotations. You are familiar with basic histological and molecular techniques. Knowledge of more sophisticated methods (e.g. flow cytometry, cell culture) is of advantage. You are keen on learning about new methodologies. You are a teamworker but also able to develop your own ideas independently and find solutions for open questions and challenges. You should be familiar with basics of data analysis, literature research and scientific writing.

Offering an international training scheme designed to develop and advance future leaders in men's health research, IRTG is looking for highly motivated, committed and persistent candidates showing excellent qualifications. A prerequisite for participation is a degree of top 15 % and a class rank of top 20%. A very good command of English (written and spoken) and of standard software is also mandatory.
Anfangsdatum: 14. Februar 2018
Geschätzte Dauer: 3 years
Bezahlung: first stipend, later employment E13, TV-H (65%)
Sonstiges: We are a dynamic young team located at the Faculty of Veterinary Medicine. We have built up intense collaborations with the local clinic of urology and andrology in Giessen and by this are able to combine both access to testicular tissue and semen samples and a smooth processing of clinical samples in our labs. Moreover, we have close collaborations with all andrological core facilities in Germany. We can offer modern lab facilities, equiment and methodological expertise in a wide histological and molecular biological field. Beside working on a clearly defined project with intensive supervision, the student is fostered to bring in own ideas and work also independently within his or her project. By this, the doctoral student can develop in the exciting scientific field of reproductive medicine and is able to establish an own standing in the scientific community.

The Monash-JLU IRTG focuses on male reproductive health and medicine undertaken at basic and translational research centres in both Australia and Germany, capitalizing on the complementary strenghts at the two partner universities. It fosters an intellectural environment building local and international research capacity.