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Archiv-Übersicht     Angebot Nr. 12720

Angebotsdatum: 2. März 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: CUTRADE - Chemical Uncoupling of Growth-Defense-Tradeoffs

Institut: Molekulare Pflanzenphysiologie
Adresse:
Prof. Stefan Hoth
Ohnhorststrasse 18
22609 Hamburg
Tel.: +49 40 42816-556   Fax.:
Bundesland: Hamburg
Homepage: http://https://www.biologie.unihamburg. de/forschung/molekular-und-zellbiologie/molpflphys.html
E-Mail Kontakt: mail

Beschreibung: Survival rate in the presence of pathogens and biomass production determine plant productivity.
In this project chemical genetic screens will be performed on a well-established model system
for autoimmunity to find chemicals that uncouple growth-defense-tradeoffs in plants.
These substances will keep immune responses high, but allow for wildtype-like growth.
Methoden: The PhD student in this project will optimize the effect of these substances by organic chemical synthesis
in the lab of Prof. Dr. Chris Meier at the Department of Chemistry and search for the
plant receptor(s) of a given CU-TRADE chemical.
Anfangsdatum: 16. April 2018
Geschätzte Dauer: 3 years
Bezahlung: German public sector scale TV-L E13, 65%.
Papers: Tong M. et al: E3 ligase SAUL1 serves as a positive regulator of PAMP-triggered immunity and its homeostasis is monitored by immune receptor SOC3. New Phytol. 2017 Sep;215(4):1516-1532.
Disch EM et al: Membrane-Associated Ubiquitin Ligase SAUL1 Suppresses Temperature- and Humidity-Dependent Autoimmunity in Arabidopsis. Mol Plant Microbe Interact. 2016 Jan;29(1):69-80.
Vogelmann K et al: Early senescence and cell death in Arabidopsis saul1 mutants involves the PAD4-dependent salicylic acid pathway. Plant Physiol. 2012 Aug;159(4):1477-87.
Sonstiges: The position commences earliest on April 16 2018 but can also be taken at a later timepoint.
Please send your applications including a cover letter, curriculum vitae, and copies of degree certificate(s) until March 20, 2018.

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