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Archiv-Übersicht     Angebot Nr. 12736

Angebotsdatum: 12. März 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Humanmedizin > Biochemie
Titel des Themas: PhD in Epigenetics

Institut: Institute of Biochemistry
Adresse:
Prof. Tilman Borggrefe
Friedrichstrasse 24
35392 Giessen
Tel.: (49)-641—9947400   Fax.:
Bundesland: Hessen
Homepage: http://https://www.uni-giessen.de/fbz/fb11/institute/biochemie/forschungbiochemie
E-Mail Kontakt: mail

Beschreibung: At the Institute of Biochemistry, University of Giessen (Germany) a PhD-position is available within the chromatin network TRR81 to study chromatin-based mechanisms of gene regulation. In particular, our laboratory is interested to understand Notch-driven gene regulation in T-lymphocytes and leukemia. Candidates should have a degree in biology/biochemistry or equivalent and good knowledge in molecular biology and/or cell biology is required.

We offer a competitive, international research environment as part of the already existing chromatin research network (TRR81, Giessen/Marburg/Bad Nauheim/Rotterdam). The working language is English. Giessen is a pleasant University town that hosts one the oldest botanical garden in Germany and represents one of the international center where the modern organic chemistry developed. Giessen is approximately 50 km away from Frankfurt am Main and 20 km from Marburg. Salaries will be according to E13/2. Details can be obtained from Dr. Tilman Borggrefe (Tilman.Borggrefe@biochemie.med.uni-giessen.de).

Candidates should send their application, including a motivational letter, their CV and a list of two potential referees to:
Tilman.Borggrefe@biochemie.med.uni-giessen.de
Methoden: Biochemistry
Molecular Biology
Cell Biology
Anfangsdatum: 1. Juni 2018
Geschätzte Dauer: 3-4 years
Bezahlung: E13/2
Papers: 1) Oswald, F., Rodriguez, P., Giaimo, B., Antonello, Z., Mira, L., Mittler, G. Thiel, V., Collins, K., Tabaja, N., Cizelsky, W., Radenz, M., Kühl, S., Kühl, M., Ferrante, F., Hein, K., Kovall, R., Dominguez, M. and Borggrefe, T. (2016) A phospho-dependent mechanism involving NCoR and KMT2D controls a committed chromatin state at Notch target genes. Nucleic Acids Research 44(10):4703-20. doi: 10.1093/nar/gkw105.



2) Hein, K. et al. (2015) Site-specific methylation of Notch1 controls amplitude and duration of the Notch1 response. Science Signaling 8(369):ra30, doi: 10.1126/scisignal.2005892.

3) Xu, et al.. (2017). The RBP-J/L3MBTL3 axis promotes the repression of Notch signaling by the histone demethylase KDM1A. EMBO J. 36(21):3232-3249. doi: 10.15252/embj.201796525.

4) Pitulescu et al. (2017) Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. Nature Cell Biology doi: 10.1038/ncb3555.

5) Thiel, V. et al. (2017) Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation. Leukemia doi: 10.1038/leu.2017.105.


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