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Archiv-Übersicht     Angebot Nr. 12746

Angebotsdatum: 19. März 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: PhD Student in Immuno-Allergology / 3 year fixed-term contract (up to 4 years), full time

Institut: Luxembourg Institute of Health
Frau Christelle Massaux
1 A-B, rue Thomas Edison
1445 Luxembourg / G.D. of Luxembourg
Tel.:    Fax.:
Homepage: http://https://www.lih.lu/jobs/detail/phd-student-in-immuno-allergology-ch0318-12749
E-Mail Kontakt: mail

Beschreibung: Luxembourg Institute of Health is a public research organisation at the forefront of biomedical sciences. With its strong research expertise in oncology, population health, infection and immunity based on human biological samples, its research activities impact on people’s health. At the Luxembourg Institute of Health, devoted scientists investigate disease mechanisms to develop new diagnostics, innovative therapies and effective tools to implement personalised medicine. The institution is the first supplier of public health information in Luxembourg, a strong cooperation partner in local and international projects and an attractive training place for ambitious early-stage researchers.

In the context of the CORE “IRGal” funded project (FNR) Dr Christiane Hilger (PI of Molecular and Translational Allergology
Research Group) is looking to recruit a :

PhD Student in Immuno-Allergology

3 year fixed-term contract (up to 4 years), full time

Targeting Key Factors Involved in Immune Reactions mediated by Tick Bites to the Carbohydrate alpha-Gal.
Ticks are considered worldwide as important vectors of animal and human diseases. Most recently, tick bites have emerged as trigger of anaphylactic reactions in humans. In particular, tick bites are considered to induce the generation of specific IgE-antibodies directed at the carbohydrate galactose-alpha-1,3-galactose (alpha-Gal). These serum IgE-antibodies are associated with a previously unrecognized form of delayed anaphylaxis occurring upon consumption of red meat or innards, the alpha-Gal syndrome.
Whereas there is strong evidence that ticks are the sensitizing agents, neither the molecules eliciting sensitization nor the mechanism involved in the generation of Th2 immune responses resulting in the production of specific IgE antibodies directed against alpha-Gal are identified.
The goal of this project is the investigation of the sensitizing source, the allergenic molecules involved and the mechanisms underlying the sensitization process in order to generate basic knowledge on immune responses to carbohydrates and provide new targets for therapeutic intervention.

Purpose of the position:
- Participate in the setting-up of a research project.
- Carry out and finalize a research project by writing a PhD thesis in the view of obtaining a PhD degree.
- Publish her/his results in scientific journals and/or file patents if applicable.
- Disseminate her/his results to the scientific community and the general public.

Key Skills, Experience and Qualifications:
- Master’s degree (or equivalent) in immunology or biomedical sciences.
- Excellent time management, rigor, perseverance, scientific creativity and originality, writing skills, conciseness, sense of priority and ability to work with others.
- Scientific background: Prior solid wet lab experience, skills in cell culture, FACS analysis and/or molecular biology will be considered as strong assets.
- Languages skills: fluent command of English, knowledge of another language of the European Union is an asset.

More information about the unit can be found here :


Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with the university and other research institutes.

Located in Luxembourg, LIH offers the opportunity to work in a dynamic, international and multilingual environment that values personal respect and professional achievement based on the highest intellectual and ethical standards. The remuneration for this position shall be based on qualification and experience.

Applications including a cover letter and a full curriculum vitae should be sent before 30th April 2018 through our website www.lih.lu/jobs. Ref.: CM/PhD0318/CH/DII
Anfangsdatum: 15. Mai 2018
Geschätzte Dauer: 3 year fixed-term contract (up to 4 years), full t