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Archiv-Übersicht     Angebot Nr. 12760

Angebotsdatum: 25. März 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Chemie > Biochemie
Titel des Themas: Sweet talking: How do cells use the sugars at their surface to communicate?

Institut: Max Planck Institute of Colloids and Interfaces
Dr. rer. nat. Christoph Rademacher
Am Mühlenberg 1
14476 Potsdam
Tel.:    Fax.:
Bundesland: Brandenburg
Homepage: http://www.mpikg.mpg.de/StructuralGlycobiology
E-Mail Kontakt: mail

Beschreibung: Every organism has evolved to cover its cells with a dense matrix of sugars. This fur-like structure made of glycans mediates central aspects of life such as development, differentiation and self-/non-self discrimination. In particular, multicellular organisms use this glycan shield in cell-cell communication processes in which a sender cell encodes information in the composition of the matrix, while a receiver cell utilizes a complex set of glycan-binding proteins to decode the message. How these encoding and decoding steps are accomplished is poorly understood. In particular, there is one important but unpredictable player that has been neglected so far: noise. In this project, we will investigate where the noise comes from and how it affects multicellular communication. For this we develop a simplified cell-based model which we can feed with defined input signals and record the interpretation on a single cell level. Using cutting-edge high throughput techniques we will acquire large data sets. To interpret these data, we will establish a computational analysis scheme based on Machine Learning. Combining a modular, experimental system with powerful computational data analysis, we are then able to explore the fundamental determinants of the glycan code.
Methoden: Cell culture, molecular biology, flow cytometry, microscopy, computational biology, machine learning.
Anfangsdatum: 1. August 2018
Geschätzte Dauer: 3
Bezahlung: yes
Sonstiges: Deadline for applications will be May 11, 2018.
Project description: https://imprs.mpikg.mpg.de/research/projects-2018/prj2k18-34
Please apply online: https://imprs.mpikg.mpg.de/application