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Archiv-Übersicht     Angebot Nr. 12768

Angebotsdatum: 29. März 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: WNT-dependent regulation of neuroinflammation

Institut: Surgical Sciences, University of Otago
Prof. Jarek Maciaczyk
Heinrich-Heine University, Medical Faculty, Mooren
40225 Düsseldorf
Tel.: +492118108013   Fax.:
Homepage: http://https://www.ncbi.nlm.nih.gov/pubmed/?term=maciaczyk+j
E-Mail Kontakt: mail

Beschreibung: Wnt signalling is widely involved in development and disease. The group leader has vast experiences in experimental models of WNT and its utility in advancing translational application particular in brain cancers and neuropathic pain. The aim of the project is the development of non-invasive imaging enabling to monitor immunogenic processes triggered by human glioma cells and in in vitro/in vivo neuropathic pain models, focusing on the activation of T-cells and microglia. This approach will employ Raman spectroscopy as a fast and non-invasive technology that provides label free imaging of biological matters including the visualization of brain cancer invasion and immune system activation. This setup enables to work out spectral fingerprints of activated T-cells/microglia in relation to WNT activity in glioblastoma cells cultures and neuropathic pain models. The project is embedded in close collaboration with brain cancer research labs in Europe (Dusseldorf, Germany; Lublin, Poland) and the United States (Johns Hopkins, Baltimore, USA) with an intensive local, national and international exchange being an important factor contributing to the successful development of the research.
Methoden: Molecular biology: molecular cloning, RT- qPCR, RNAseq
Cell culture techniques: transfection, reporter assays, siRNA knockdown
Cell biology: immunofluorescence, confocal microscopy, flow cytometry
Animal models: transplantation, peripheral nerve injury model, spinal cord stimulation
Anfangsdatum: 29. März 2018
Geschätzte Dauer: 4 Jahre
Bezahlung: 100%, full time payment
Sonstiges: Eligibility: Doctoral degree in a relevant natural science; Experience in cell or molecular biology, multivariate analysis.

Note: Please send applications by 20th of April including full letter of motivation, CV and reference letter of the previous MS/PhD supervisor to Prof. Jarek Maciaczyk jarek.maciaczyk@otago.ac.nz.

Only applications send IN A SINGLE PDF FILE will be considered.