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Archiv-Übersicht     Angebot Nr. 12775

Angebotsdatum: 6. April 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Biochemie
Titel des Themas: tRNA mimicry: RNA signals in viral and cellular mRNAs that are regulated by glycyl-tRNA synthetase

Institut: Biochemisches Institut
Prof. Michael Niepmann
Friedrichstrasse 24
35392 Giessen
Tel.:    Fax.:
E-Mail Kontakt: mail

Beschreibung: In the context of a DFG-funded Research Training Group "Regulatory networks in the mRNA life cycle: from coding to noncoding RNAs" (RTG 2355), a Ph.D. position is available at Justus Liebig University Giessen in the research group of Prof. Dr. Michael Niepmann at the Institute of Biochemistry from July 1st, 2018.
This RTG is a research and qualification programme focusing on RNA-based gene-regulatory networks in a broad range of model organisms. The two foci of interest in the participating groups are, first, the main stages of the mRNA life cycle, from transcription and mRNP biogenesis, RNA processing, translation, to mRNA decay; second, representative examples of regulatory noncoding RNA classes (eukaryotic microRNAs, long noncoding RNAs, circular RNAs, prokaryotic small RNAs). Thesis projects will cover a wide spectrum of approaches: from classical RNA biochemistry and cell biology to RNA-Seq and computational analyses. Specific research topics range from molecular principles of gene expression to disease-relevant questions in molecular medicine and innovative applications of RNA biotechnology.
This project focuses on the regulation of RNA function by cellular RNA binding proteins. RNA viruses often recruit cellular RNA binding proteins to facilitate replication of their RNA genomes in the host cell. The cellular glycyl-tRNA synthetase (GARS) binds to a conserved tRNA-like element in Poliovirus RNA and regulates Poliovirus translation. Such GARS binding elements are also present in the genomic RNAs of other pathogenic Picornaviruses like Entero- and Coxsackieviruses. We want to characterize the role of GARS binding elements in Enterovirus gene expression, replication and pathogenesis. We will also search for possible GARS target sites in human mRNAs by global analyses of GARS binding to RNA.
Ideal candidates have a M.Sc. degree (or equivalent) in Virology, Biochemistry, Biology or similar fields and are highly motivated to conduct multidisciplinary research. Practical experience in virology is preferred.
The salary is in accordance with the German public service salary scale (E13 TV-H, 65 %) for up to three years. The Justus Liebig University of Giessen is an equal-opportunity employer and places particular emphasis on fostering career opportunities for women. Disabled persons with equivalent aptitude will be favored.
Please find more information and the contact address at www.uni-giessen.de/RTG2355. Applications should be submitted directly to Prof. Niepmann. All application documents (motivation letter, CV, transcripts of records, at least two references or contact addresses of referees) should be contained within a single PDF file.
Anfangsdatum: 1. Juli 2018
Geschätzte Dauer: 3 Jahre
Bezahlung: E13 (65%)