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Archiv-Übersicht     Angebot Nr. 12786

Angebotsdatum: 11. April 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Chemie > Biochemie
Titel des Themas: Functional analysis of the adhesion GPCR class in Drosphila

Institut: Rudolf-Schönheimer-Institut für Biochemie
Dr. rer. nat. Nicole Scholz
Johannisallee 30
04103 Leipzig
Tel.: +49 (341) 97-22145    Fax.: +49 (341) 97-22109
Bundesland: Sachsen
Homepage: http://www.adhesiongpcr.de/en_us
E-Mail Kontakt: mail

Beschreibung: A fixed-term for 3 years PhD position is open at the University of Leipzig, DFG Research Unit 2149 “Elucidation of Adhesion-GPCR signaling”.
In our group we focus on understanding the biology of a specific group of G protein-coupled receptors, namely Adhesion G protein-coupled receptors (aGPCRs). Although these biosensors constitute the second largest group of GPCRs, their functions remain incompletely understood.
One striking feature of aGPCRs is their vivid splicing activities, which may lead to the production of several receptor variants that may impart different functions. However, what these differences might be remains to be discovered.

Recently we uncovered that the mRNA of the prototype aGPCR Latrophilin is severely spliced resulting in differentially sized receptor molecules. Based on this finding we aim to investigate cause and functional consequence of such aGPCR-specific splicing events on cellular and organismic level.

To this end we are searching for a motivated student, who is interested in learning and employing a combination of in vitro and in vivo (Drosophila melanogaster) methodologies and above all is curious to study these peculiar GPCRs. The PhD student is expected to work responsibly and independently. A solid knowledge of English is mandatory.

We offer a DFG-financed PhD position. The salary is in accordance with the German public service salary scale (E13 TV-L, 65%) for up to three years (availability of the third-party funds).

The position is available starting now.
Application deadline is April 30, 2018.

If you hold Master`s or diploma degree in biology, biochemistry or chemistry and you are interested in basic scientific research in a stimulating and international environment we would like to encourage your application.
Anfangsdatum: 1. Mai 2018
Geschätzte Dauer: 3 Jahre