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Angebotsdatum: 24. April 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Chemie > Angewandte Makromolekulare Chemie
Titel des Themas: Double Hydrophilic Brush Block Copolymer Self-assemblies for Tissue-Engineering

Institut: Max-Planck-Institut für Kolloid- und Grenzflächenforschung
Adresse:
Dr. rer. nat. Bernhard Schmidt
Am Mühlenberg 1
14476 Potsdam
Tel.:    Fax.:
Bundesland: Brandenburg
Homepage: http://https://imprs.mpikg.mpg.de/research/projects-2018/prj2k18-37
E-Mail Kontakt: mail

Beschreibung: Phase separation based on hydrophilic polymers plays an important role in cellular processes. Moreover, double hydrophilic brush block copolymers (DHBC), e.g. proteoglycans, have significant functions in biological systems. Recently, self-assembly of synthetic DHBCs in aqueous solution was observed, e.g. into vesicles, droplets, micelles or particles. Nevertheless, the formation of DHBC-based materials and their properties are still rather unexplored.

In the present project the utilization of DHBC-based self-assemblies for biomimetic materials will be studied. After synthesis of the respective block copolymer via controlled polymerization methods, the self-assembly in aqueous solution will be investigated. More important is the assessment of the interaction with biopolymers and the ability to form soft composite materials. The effect of DHBC architecture on the final materials properties will be studied. The acquired knowledge can be utilized to obtain tailor-made biomaterials.
Methoden:
Anfangsdatum: 1. August 2018
Geschätzte Dauer: 30 Monate
Bezahlung:
Papers: Bernhard V. K. J. Schmidt, Double-hydrophilic block copolymer self-assembly in aqueous solution, Macromol. Chem. Phys. 2018, 219, 1700494.
Christine Weber, C. Remzi Becer, Richard Hoogenboom and Ulrich S. Schubert, Lower Critical Solution Temperature Behavior of Comb and Graft Shaped Poly[oligo(2-ethyl-2-oxazoline)methacrylate]s, Macromolecules, 2009, 42 (8), 2965–2971.
Sonstiges: Application via imprs.mpikg.mpg.de

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