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Archiv-Übersicht     Angebot Nr. 12834

Angebotsdatum: 4. Mai 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: Role of Plakophilin 1 in Inflammatory Signaling

Institut: Institut für Molekulare Medizin
Adresse:
Dr. rer. nat. René Keil
Kurt-Mothes-Str. 3a
06120 Halle
Tel.:    Fax.:
Bundesland: Sachsen-Anhalt
Homepage:
E-Mail Kontakt: mail

Beschreibung: The Institute of Molecular Medicine at the Martin-Luther-University Halle-Wittenberg is seeking for a highly talented and motivated PhD candidate for a DFG-funded project on inflammatory signaling in keratinocytes. The project deals with the interdependent regulation of intercellular cohesion and inflammatory processes, involving approaches in cell biology, molecular biology, biochemistry, and work with mouse models. The PhD position (E13 TV-L, 65%) is available immediately and limited to three years.

We offer:
- exciting, interdisciplinary research at international level.
- an inspiring scientific environment in the excellent equipped, recently opened Charles-Tanford-Protein-Center at the Weinberg Campus.
- close supervision and mentoring.
- the opportunity to present results at international conferences.

To apply, you must:
- hold a university degree (Master’s degree or equivalent) in the fields of life sciences (biology, biochemistry, or related disciplines).
- have strong interest and experience in the field of cell biology, molecular biology and immunology
- be able to work efficiently, independently as well as in a team.
- be highly proficient in spoken and written English.

A FELASA category B certificate or equivalent is a plus, but is not required.

Your application should consist of a motivation letter including a brief statement of research interests, a CV including an overview of techniques and methods used in the past, transcripts or degree certificates, a list of publications/awards, and contact details of two referees. Please submit your full application (in electronic form as a single pdf) until May 31st, 2018 to Dr. René Keil; E-mail: rene.keil@uk-halle.de

The Martin-Luther-University Halle-Wittenberg is an equal opportunity employer. Disabled candidates with equal qualifications will be given preference. Women are strongly encouraged to submit an application. The announcement takes place pending on fund availability and any possible budget restriction. Application expenses cannot be reimbursed by the Martin-Luther-University.
Methoden:
Anfangsdatum: 1. August 2018
Geschätzte Dauer: 3 years
Bezahlung: E13 TV-L, 65%
Papers: 1. Rietscher, K., R. Keil, A. Jordan, and M. Hatzfeld, 14-3-3 proteins regulate desmosomal adhesion via plakophilins. J Cell Sci, 2018.
2. Hatzfeld, M., R. Keil, and T.M. Magin, Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics. Cold Spring Harb Perspect Biol, 2017. 9(6).
3. Rietscher, K., A. Wolf, G. Hause, A. Rother, R. Keil, T.M. Magin, M. Glass, C.M. Niessen, and M. Hatzfeld, Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo. J Invest Dermatol, 2016. 136(7): p. 1471-1478.
4. Keil, R., K. Rietscher, and M. Hatzfeld, Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3. J Invest Dermatol, 2016. 136(10): p. 2022-2029.
5. Keil, R. and M. Hatzfeld, The armadillo protein p0071 is involved in Rab11-dependent recycling. J Cell Sci, 2014. 127(Pt 1): p. 60-71.
6. Hatzfeld, M., A. Wolf, and R. Keil, Plakophilins in desmosomal adhesion and signaling. Cell Commun Adhes, 2014. 21(1): p. 25-42.
7. Nolze, A., J. Schneider, R. Keil, M. Lederer, S. Huttelmaier, M.M. Kessels, B. Qualmann, and M. Hatzfeld, FMRP regulates actin filament organization via the armadillo protein p0071. RNA, 2013. 19(11): p. 1483-96.
8. Keil, R., J. Schulz, and M. Hatzfeld, p0071/PKP4, a multifunctional protein coordinating cell adhesion with cytoskeletal organization. Biol Chem, 2013. 394(8): p. 1005-17.
9. Keil, R., C. Kiessling, and M. Hatzfeld, Targeting of p0071 to the midbody depends on KIF3. J Cell Sci, 2009. 122(Pt 8): p. 1174-83.
10. Keil, R., A. Wolf, S. Huttelmaier, and M. Hatzfeld, Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin. Cell Cycle, 2007. 6(2): p. 122-7.
11. Wolf, A., R. Keil, O. Gotzl, A. Mun, K. Schwarze, M. Lederer, S. Huttelmaier, and M. Hatzfeld, The armadillo protein p0071 regulates Rho signalling during cytokinesis. Nat Cell Biol, 2006. 8(12): p. 1432-40.


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