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Archiv-Übersicht     Angebot Nr. 12867

Angebotsdatum: 5. Juni 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Physik > Nanophysik
Titel des Themas: Biomineralization of greigite

Institut: Biosciences and Biotechnologies
PD Damien Faivre
CEA Cadarache
13108 Saint-Paul-lez-Durance (France)
Tel.:    Fax.:
Homepage: http://biam.cea.fr/drf/biam/english/Pages/laboratories/lbc/magneto-bacteria.aspx
E-Mail Kontakt: mail

Beschreibung: The Cell Bioenergetics Lab focuses on interdisciplinary research in the field of microbiology and biotechnological applications. In this context, the “Magnetotactic Bacteria” group focuses on the understanding of biomineralization and the development of new materials for medicine. In this context, funding is available from the CEA and we invite applications for:

PhD Student

Iron oxides are widely used in medical applications because of their magnetic properties, which depend on their size. While chemical syntheses produce polydisperse particles with a wide variety of magnetic behaviors, magnetotactic bacteria are capable of producing particles of highly conserved size and morphology. These biogenic particles are further surrounded by a membrane ensuring their stability in biological fluids and allowing their functionalization by genetic approaches. We have recently demonstrated that these particles are effective contrast agent for magnetic resonance imaging (MRI).
The laboratory has isolated in culture the first bacterial strain that is not only capable of producing nanoparticles of magnetite, but also nanoparticles of greigite. Greigite is an iron sulphide, with a structure equivalent to that of magnetite. The biomineralization of greigite is just beginning to be studied, while this mineral also exhibits interesting properties for biotechnological applications.
The candidate will therefore (i) study the processes of biomineralization of greigite, in particular the chemical species that precede its formation, in order to be able in the medium term to form greigite by biomimetic chemical way, (ii) analyze the magnetic properties of bacterial greigite particles; and (iii) exploit the particles’ potential for biotechnological applications.
Methoden: X-ray Spectroscopy
Electron microscopy
Anfangsdatum: 5. Juni 2018
Geschätzte Dauer: 3 years
Bezahlung: ca 2000 € before Taxes
Papers: Boucher et al., Genetically tailored magnetosomes used as MRI probe for molecular imaging of brain tumor, Biomaterials, 2017
Faivre, D. and T. Ukmar Godec, From Bacteria to Mollusks: The Principles Underlying the Biomineralization of Iron Oxide Materials, Angew. Chem. Int. Ed., 2015.