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Archiv-Übersicht     Angebot Nr. 12877

Angebotsdatum: 13. Juni 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Pathologie
Titel des Themas: PhD student position in translational cancer research and RNA biology

Institut: Institut für Pathologie
Adresse:
Dr. med. Monika Hämmerle
Magdeburger Str. 14
06112 Halle (Saale)
Tel.:    Fax.:
Bundesland: Sachsen-Anhalt
Homepage:
E-Mail Kontakt: mail

Beschreibung: The newly established Junior Research group (AG Hämmerle) at the Institute of Pathology, Martin-Luther-University Halle-Wittenberg, is seeking an exceptionally talented and highly motivated PhD student with a strong interest in translational cancer research and RNA biology.
The graduate student position (E13 TV-L, 65%) is available immediately and limited to three years.

The successful candidate will investigate the molecular and biological function of cancer-associated and prognostically relevant long non-coding RNAs (lncRNAs) and RNA-binding proteins (RBPs) in pancreatic adenocarcinoma with special emphasis on the tumor microenvironment. Specifically, the PhD candidate will (i) establish cellular models of cancer-associated lncRNAs and RBPs (using CRISPR/Cas9 etc.); (ii) extensively characterize these engineered cell lines phenotypically in vitro and in vivo; (iii) analyze tissue-specific expression of RBPs and lncRNAs using in-situ hybridization and immunohistochemical techniques and (iv) mechanistically characterize the most interesting lncRNAs/RBPs and their dependencies in more detail using biochemical as well as molecular and cell biology methods (e.g. Cloning, qRT-PCR, RNA affinity purification, CLIP).

Applicants must hold a Diploma or Master’s degree in the field of molecular biology, biochemistry, molecular medicine, bioinformatics or related disciplines. The successful candidate is a highly motivated, creative, ambitious, and hard-working individual with excellent grades who is passionate about making a difference through cancer research. A reliable and accurate scientific working ethic, and the ability to work efficiently, independent as well as in a team, is a necessity. An excellent written and oral command of English paired with strong communication skills is essential. The ideal candidate has a solid background in the field of cancer biology and expertise in molecular and cellular biology, with a specific focus on the techniques described above. Knowledge in statistics and bioinformatics would be advantageous.

This position provides a unique opportunity for the candidate to be innovative and to work on a multidisciplinary and translational topic using and developing cutting-edge technologies. We offer extensive proven expertise in RNA and cancer biology (Cancer Cell 2018; Nat Commun 2017; Cell Reports 2016; JCI 2016; Hepatology 2014; Cancer Research 2013; Hepatology 2013), a close supervision and mentoring as well as an international environment with state-of-the-art research facilities.

Applications should consist of (I) a motivation letter, (II) a recent curriculum vitae incl. an overview of techniques and methods used in the past/list of publications, (III) academic degrees and certificates, and (IV) contact information or reference letters of 2-3 referees.
Please submit your full application (in electronic form preferentially as a single pdf) mentioning the registration number 7-077/18-H in the subject line until June 27, 2018 to Monika Hämmerle, M.D., Ph.D (monika.haemmerle@uk-halle.de).

The Martin-Luther-University Halle-Wittenberg is an equal opportunity employer. Disabled candidates with equal qualifications will be given preference. Women are strongly encouraged to submit an application.
The announcement takes place pending on fund availability and any possible budget restriction. Application expenses cannot be reimbursed by the Martin-Luther-University.
Methoden: Cell and Molecular biology techniques
CRISPRi/CRISPRa
RNA affinity purification
Protein-RNA-interaction studies (e.g. eCLIP)
RNA in situ hybridization
Gene expression analysis (RNA-Seq)
Anfangsdatum: 1. August 2018
Geschätzte Dauer: 3 Jahre
Bezahlung: E13 TV-L (65%)
Papers: Haemmerle M et al., Cancer Cell (2018)
Haemmerle M et al., Nat Commun. (2017)
Gutschner T, Haemmerle M et al., Cell Rep. (2016)
Haemmerle M et al., JCI (2016)
Gutschner T, Hämmerle M et al., Hepatology (2014)
Hämmerle M et al., Hepatology (2013)
Gutschner T, Hämmerle M et al., Cancer Res. (2013)
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