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Archiv-Übersicht     Angebot Nr. 12878

Angebotsdatum: 13. Juni 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: The role of cell adhesion molecule JAM-A in the regulation of cell migration

Institut: Institut für Med. Biochemie, ZMBE
Adresse:
Prof. Klaus Ebnet
Von-Esmarch-Str. 56
48149 Münster
Tel.: 0251 8352127   Fax.:
Bundesland:
Homepage: http://https://www.medizin.uni-muenster.de/zmbe/die-institute-des-zmbe/inst-fuer-medizinische-biochemie/institutassoziierte-forschergruppe-prof-ebnet/
E-Mail Kontakt: mail

Beschreibung: We study the role of cell adhesion molecules of the JAM family in epithelial cells, endothelial cells and tumor cells. We have recently found that the JAM family member JAM-A regulates the dynamics of the actin cytoskeleton and has a strong influence on cell migration. In this project, we will analyze the role of JAM-A during different modes of cell migration, like single cell migration or collective cell migration, and we will characterize the underlying molecular mechanisms. As model systems, we use various types of epithelial cells and tumour cells. We apply primarily methods of molecular biology (molecular cloning, mutagenesis, PCR), protein biochemistry (expression and purification of recombinant proteins, pulldown experiments, immunoprecipitation) and fluorescence microscopy (confocal microscopy, live cell imaging). You should be interested in molecular cell biology, open to new technologies, and highly motivated. We offer an interesting project, intensive supervision, and a strong scientific environment. For additional information, feel free to contact us by telephone or e-mail, or visit our web site ("zmbe münster"). If you are interested, please send your application as a pdf document to the address below.
Methoden: Molecular Biology: Cloning, PCR, Mutagenesis
Proteinbiochemistry: Generation and purification of recombinant proteins, protein-protein interaction (pulldown, Co-immunoprecipitation)
Anfangsdatum: 1. August 2018
Geschätzte Dauer: 3 - 4 Jahre
Bezahlung: TVL-E13/65%
Papers: REVIEWS:

1. Steinbacher T, Kummer D and Ebnet K (2018). Junctional Adhesion Molecule-A: Functional diversity through molecular promiscuity. Cell. Mol. Life Sci.75:1393–1409.

2. Kummer D and Ebnet K (2018). Junctional Adhesion Molecules (JAMs): The JAM - Integrin connection. Cells. Mar 26;7(4). pii: E25. doi: 10.3390/cells7040025.

3. Ebnet K (2017). Junctional adhesion molecules (JAMs): Cell adhesion receptors with pleiotropic functions in cell physiology and development. Physiol. Rev. 97: 1529-1554

ORIGINAL ARTICLES

1. Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V and *Ebnet K (2016). VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Mol.Biol.Cell 27: 2811-2821.

2. Fededa JP, Esk C, Mierzwa B, Stanyte R, Yuan S, Zheng H, Ebnet K, Yan W, Knoblich JA and Gerlich DW (2016). MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development. EMBO J. 35: 2386–2398.

3. Squarr AJ, Brinkmann K, Chen B, Steinbacher T, Ebnet K, Rosen MK and Bogdan S (2016). Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation. J. Cell Biol. 212: 591-603.

4. Tuncay H, Brinkmann BF, Steinbacher T, Schürmann A, Gerke V, Iden S and *Ebnet K (2015). JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128.
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