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Archiv-Übersicht     Angebot Nr. 12893

Angebotsdatum: 18. Juni 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Sonstiges
Titel des Themas: PhD Student in Cancer Research - 2-year fixed-term contract (renewable for 2 years), full time. Start date: October 2018

Institut: Luxembourg Institute of Health
Frau Virginie De Landsheer
1A Rue Thomas Edison
1445 Strassen - Luxembourg
Tel.:    Fax.:
Homepage: http://https://www.lih.lu/jobs/detail/phd-student-in-cancer-research-jp0618-12779
E-Mail Kontakt: mail

Beschreibung: Luxembourg Institute of Health (LIH) is the leading public research center in Luxembourg for basic, pre-clinical and clinical research in biomedicine and public health. Our clinically-oriented biomedical research activities in Oncology, Infection & Immunity and Population Health encompass the generation of knowledge on the pathogenesis, diagnosis and treatment of diseases with large impacts on public health and the epidemiological surveillance of these diseases. With the mission to deliver scientific, economic and societal value for Luxembourg, LIH aims to translate knowledge into clinical applications impacting on healthcare systems while shaping personalized medicine.

To be part of the Tumor Stroma Interactions research group (Head: PI: Dr. E. Moussay and Dr. Jérôme Paggetti) within the Laboratory of Experimental Cancer Research of LIH, we are currently looking for:

PhD Student in Cancer Research
2-year fixed-term contract (renewable for 2 years), full time. Start date: October 2018.

Background: Chronic Lymphocytic Leukemia (CLL) represents the most frequent leukemia in adults. Despite recent advances in treatments, CLL remains a deadly uncurable disease. This cancer is caracterized by an accumulation of abnormal, apoptosis resistant, B lymphocytes in the blood and lymphoid organs of the patients. CLL progression is highly dependent on complex interactions between tumor cells and their microenvironment. Indeed, CLL cells can modify stromal cells and immune cells to promote their survival and to escape from the immune surveillance system.

Objectives: Our team focuses on the mechanisms leading to leukemia progression, in particular the influence of CLL cells on stromal cells and immune cells located in their microenvironment, with the goal to identify new prognostic markers and therapeutic targets.

Training and research environment: Tumor Stroma Interactions research group is a dynamic and multinational team whose current members originate from France, Belgium, Germany and Italy. It belongs to the Department of Oncology, whose research activities focus on the cellular and molecular mechanisms of tumor progression using a wide range of cutting edge technologies, including genomic, transcriptomic and proteomic analyses, as well as in vitro and in vivo imaging modalities using state-of-the art animal models for cancer research. PhD student will be in charge of a TELEVIE funded project that aims to explore the interplay between tumor cells and regulatory T cells, and will be co-supervised by Dr. E. Moussay (PI), Dr. J. Paggetti (PI).

Recent related reference (open access): Paggetti J, et al. Exosomes released by chronic lymphocytic leukemia cells induce cancer- ssociated fibroblast formation. Blood 126(9):1106-17.
Wierz M, et al. Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia. Blood 131(14):1617-1621. (IF:13.164)

Key Skills, Experience and Qualifications:
- Master’s degree in Biomedical Sciences or Immunology. Prior experience in cancer research would be an advantage, but is not mandatory.
- Experience in cell culture, PCR, Western-Blot and flow-cytometry techniques.
- Mouse experimentation practice and FELASA (or equivalent) diploma would be considered as an asset.
- Excellent time management, rigor, perseverance, scientific creativity and originality, writing skills, sense of priority and ability to work with others.
- Fluency in English is mandatory.

Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with universities and other research institutes.

Scientific contact:
Dr. Jérôme PAGGETTI, PhD
84 Val Fleuri
L-1526 Luxembourg
Tel: 00352 26 970 340

More information about the group can be found here : http://tsi.lih.lu

Located in Luxembourg, LIH offers the opportunity to work in a dynamic, international and multilingual environment that values personal respect and professional achievement based on the highest intellectual and ethical standards.

Applications including a cover letter detailing your motivation and a full curriculum Vitae should be sent before 31st July, 2018 through our website https://www.lih.lu/jobs/detail/phd-student-in-cancer-research-jp0618-12779 with the ref .: VD/PHDCR0618/JP/LEC
Anfangsdatum: 1. Oktober 2018
Geschätzte Dauer: 2-year fixed-term contract (renewable for 2 years)