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Archiv-Übersicht     Angebot Nr. 12903

Angebotsdatum: 22. Juni 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Chemie > Anorganische Chemie
Titel des Themas: Chemical topography of metal-associates allergens on non-planar everyday items

Institut: International Giessen Graduate Centre for the Life Sciences (GGL)
Frau Wagenbach
Leihgesterner Weg 52
35392 Gießen
Tel.:    Fax.:
Bundesland: Hessen
Homepage: http://www.uni-giessen.de/ggl/overview/application
E-Mail Kontakt: mail

Beschreibung: Metal-organic allergens on surfaces of objects of daily use, such as jewelry or coins, are of increasing relevance in multiple dermatologic problems. The chemistry behind the formation and reaction of metal-associated allergens is widely unexplored. Complexes of nickel, copper and tin are known to be easily formed through contact of metal alloys with ubiquitous organic compounds from, e.g., skin secretions. The project aims to investigate the structure, occurence, and reactivity of typical organic reactants and of formed metal complexes on the three-dimensional surface of jewelry, decoration and coins, using atmopsheric-pressure matrix-assisted laser desorption/ionization mass spectrometry. The influence of topographic effects shall be described by the use of 3D-surface mass spectrometry imaging techniques on the micrometer scale, uniquely available at the Giessen labs. The chemistry of complex formation will be studied in vitro by organometallic synthesis, and their spontaneous formation on real objects will be simulated.
Methoden: Creative thinking and English writing skills; solid training in inorganic, organic and analytical chemistry; interest in development and application of scientific instruments, of chemical synthesis and of powerful software tools; interest in mass spectrometry, coordination chemistry, medicinal chemistry.
Anfangsdatum: 1. Oktober 2019
Geschätzte Dauer: 3 years
Bezahlung: supervision, lab space and personal funding are av
Sonstiges: This Project will be funded by a DAAD fellowship, only international applicants may apply. Successfull applicants will have access to German language course in spring 2019 and a Graduate School Scholarship of the DAAD, starting approximately in October 2019.