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Archiv-Übersicht     Angebot Nr. 12926

Angebotsdatum: 27. Juli 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Humanmedizin > Immunologie
Titel des Themas: Metabolism, Inflammation and Inflammasome Biology

Institut: Institute of Neuropathology
Prof. Olaf Groß
Breisacher Str. 66
79106 Freiburg
Tel.:    Fax.:
Bundesland: Baden-Württemberg
E-Mail Kontakt: mail

Beschreibung: The Freiburg Metabolism and Inflammation Research Group of Professor Olaf Groß at the Institute of Neuropathology, Freiburg University Medical Centre is offering a

PhD Position

Starting date: Fall 2018

We study the fundamental molecular mechanisms of inflammation and innate immunity and their integration with metabolism. Our focus is on a cytoplasmic signalling complex in macrophages known as the inflammasome that is responsible for proteolytic activation of the proinflammatory cytokine IL-1beta. We study the inflammasome at the molecular, cellular, and organismal levels using a broad range of cutting-edge technologies, and have made important contributions to the understanding of inflammasome biology and related signalling mechanisms (Schneider KS et al., Cell Rep., 2017; Groß CJ et al., Immunity, 2016; Groß O et al., Immunity, 2012; Poeck H et al., Nat. Immun., 2010; Groß O et al., Nature, 2009). In current projects, we are investigating the role of inflammasomes in auto-immune disease, the cross-talk between metabolism and the immune system, and the role of mitochondria in immune cell signalling. We are increasingly also interested in targeting metabolism of immune and cancer cells for therapy.

Your profile:
• Master’s degree (or equivalent) with a background in immunology, cell biology, biochemistry, and/or signal transduction
• Experience with types of techniques used by our laboratory
• Good English language skills
• Analytical thinker
• Highly motivated, enthusiastic for science, and have a positive and constructive work attitude
• Reliable, diligent, and capable of independent work
• Good communication skills and can work well as part of a team

We offer:
• An environment with state-of-the-art equipment and facilities (flow cytometry, proteomics, metabolomics, metabolic flux assays, next-generation sequencing, live cell imaging, high-end microscopy)
• Excellent working conditions in a dynamic, motivated group where hard and successful work does not exclude fun

Applicants with a strong interest in joining our group should submit their application (including a complete CV, transcripts of records, a cover letter clearly stating your motivation, the contact details of two or more academic referees, and (optional) a letter of recommendation as well as any other supporting documents), preferably via E-mail and as one single pdf, by August 31 2018.

For enquiries and applications please contact: nez.gross.applications@uniklinik-freiburg.de
Anfangsdatum: 27. Juli 2018
Geschätzte Dauer: 3-4 years
Bezahlung: TV-L 13 (65%)
Papers: Schneider KS et al., Cell Rep., 2017
Groß CJ et al., Immunity, 2016
Groß O et al., Immunity, 2012
Poeck H et al., Nat. Immun., 2010
Groß O et al., Nature, 2009
Sonstiges: https://www.uniklinik-freiburg.de/neuropathology/research/metabolism-and-inflammation.html