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Archiv-Übersicht     Angebot Nr. 12928

Angebotsdatum: 7. Juli 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Pathologie
Titel des Themas: Microenvironmental Control Of Hallmarks Of Cancer

Institut: Institut für Neuropathologie, JLU Giessen
PD Attila Nemeth
Aulweg 128
35392 Giessen
Tel.:    Fax.:
Bundesland: Hessen
Homepage: http://https://www.ukgm.de/ugm_2/deu/ugi_npa/5424.html
E-Mail Kontakt: mail

Beschreibung: The Institute of Neuropathology at the Justus Liebig University in Giessen, Germany, Director Prof. Till Acker, is inviting applications for


in the field of tumor biology/neurooncology. The position is available immediately for 3 years with the option for extension.

Your profile:
We are looking for enthusiastic and highly motivated applicants holding, or about to obtain an MSc degree, diploma or equivalent. The applicants should possess a strong interest in cancer research, molecular and cell biology, the ability to integrate in an international team, learn about new fields and establish new experimental techniques. Prior experience with laboratory mouse, cell culture, or tumor biology related assays will be an advantage.

Regions of low oxygen tension are common findings in malignant tumors, being associated with increased frequency of tumor invasion and metastasis, and thus critically determining the clinical behaviour and outcome of tumors. We work on a broad range of topics, primarily related to the functions of the members of the oxygen sensing pathway - HIFs, PHDs, their regulators and downstream effectors - in diverse aspects of cancer biology. We are particularly interested in understanding how stress signals from the tumor microenvironment are sensed and integrated in order to promote tumor growth and progression. The proposed projects will aim to dissect the role of the brain microenvironment in CNS metastasis with emphasis on the crosstalk of the oxygen sensing pathway with other cellular signalling pathways, including growth factor/RTK and metabolic signalling.

What we offer:
Our international team offers an open, supportive, dynamic and motivating academic environment with excellent training opportunities including the PhD graduate program of the International Giessen Graduate school for Life Sciences (GGL http://www.uni-giessen.de/cms/fbz/zentren/ggl). We have won a number of external research grants and are involved in several national and international collaborative projects.

Please send your application as a single PDF: cover letter, your CV, certificates of your qualifications, your publication list and the contact details of at least two referees until 30.09.2018 to Dr. Attila Németh (Attila.Nemeth at patho.med.uni-giessen.de)

Applicants with disabilities but otherwise equal qualifications will be preferred.
Methoden: We use a wide spectrum of methods: cloning, cell culture, biochemistry, qRT-PCR, FACS, ELISA, cell-based assays (proliferation, apoptosis, migration, 3D invasion, stem cell isolation and cultivation etc.), shRNA and CRISPR screens, proteomics, transactivation assays, virally-based gene delivery, RNAi and CRISPR silencing, immunohistochemistry, in situ hybridization, light, epifluorescence and confocal microscopy, image analysis, miRNA analyses, DNA methylation array analysis, chromatin immunoprecipitation, bioinformatic analysis, animal models and in vivo tumor models.
Anfangsdatum: 7. Juli 2018
Geschätzte Dauer: 3-4 Jahre
Papers: Dopeso et al, Cancer Research 2018;78(7):1805-1819.
Depner et al, Nat Commun. 2016;7:12329.
Filatova et al, Cancer Research 2016;76(19):5845-5856.
Henze et al, Nat Commun. 2014;5:5582.
Garvalov et al, Nat Commun. 2014;5:5577.
Sawamiphak et al, Nature 2010; 465(7297):487-91