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Archiv-Übersicht     Angebot Nr. 12940

Angebotsdatum: 12. Juli 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Tumorsuppression in Lebertumoren

Institut: Pathologisches Institut
Dr. rer. nat. Stephanie Rössler
Im Neuenheimer Feld 224
69120 Heidelberg
Tel.:    Fax.:
Bundesland: Baden-Württemberg
Homepage: http://https://www.klinikum.uni-heidelberg.de/index.php?id=138014&L=1
E-Mail Kontakt: mail

Beschreibung: The group of Dr. Stephanie Rössler at the Institute of Pathology at Heidelberg University Hospital is seeking a highly motivated PhD student.
Our laboratory is interested in the role of genetic alterations in hepatocellular carcinoma (HCC). Liver cancer is the second leading cause of cancer-related death worldwide. The high mortality rate of HCC is mainly caused by metastasis or by de novo tumor formation in the diseased liver. The project of the successful candidate will focus on the functional characterization of tumor suppressor genes on chromosome 8p in HCC.
We are looking for a highly motivated PhD student with a background in molecular biology, biochemistry or cell biology. Applicants must have a MSc degree or equivalent in Biology, Biochemistry or related fields. Expertise in tissue culture, microscopy and molecular biology is desired. We expect enthusiasm for science and strong work ethics.
We offer a friendly and productive interdisciplinary work atmosphere and state-of-the-art equipment within the newly established and DFG funded SFB TRR-209 “Liver cancer”. The PhD student will be part of the local PhD Program, which offers interdisciplinary practical training, scientific conferences, mentoring by a thesis committee of experts in the field, and a highly stimulating international research environment.
Methoden: We employ a broad range of techniques, including mouse models, molecular biology and biochemistry (protein-protein interactions), cell biology (live-cell imaging) and computational analysis to connect molecular biology and medical relevance.
Anfangsdatum: 12. Juli 2018
Geschätzte Dauer: 3 Jahre
Bezahlung: TV-L
Papers: 1.Ploeger C, Waldburger N, Fraas A, Goeppert B, Pusch S, Breuhahn K, Wang XW, Schirmacher P, Roessler S (2016) Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma. Hepatology, 64(3):828-42

Roessler S, Long EL, Budhu A, Chen Y, Zhao X, Ji J, Walker R, Jia HL, Ye QH, Qin LX, Tang ZY, He P, Hunter KW, Thorgeirsson SS, Meltzer PS, Wang XW (2012) Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival. Gastroenterology 142(4): 957-66
Sonstiges: Applications (cover letter, statement of research interests, CV, qualifications and contact information of two to three referees) should be sent in one pdf-document to Dr. Stephanie Rössler: Stephanie.Roessler@med.uni-heidelberg.de