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Archiv-Übersicht     Angebot Nr. 12984

Angebotsdatum: 11. August 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Immunologie
Titel des Themas: Activation of innate immune sensors in Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis

Institut: Medizinische Klinik und Poliklinik III, Universitätsklinikum Bonn
Dr. med. Lino Teichmann
Sigmund-Freund-Str. 25
53127 Bonn
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
E-Mail Kontakt: mail

Beschreibung: A PhD position is available for a SFB/Transregio 237 research project in the field of Autoimmunity in the group of Lino L. Teichmann at the Biomedical Center, University of Bonn Medical School, Germany.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) represent a group of serious and sometimes fatal autoimmune disorders that lead to inflammation of the microvasculature. Vessel inflammation frequently occurs in the respiratory tract and kidneys but can to various extent also afflict skin, joints, eyes, and nerves. The AAVs comprise granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), drug-induced ANCA-associated vasculitis and other diseases. Currently there is only limited experimental data available on the mechanisms governing AAV resulting from the difficulty to model these conditions in animals. Using a novel mouse model of AAV we aim to understand how the activation of innate immune sensors leads to sterile inflammation and organ destruction in AAV. The results from this project will identify key mechanisms in disease progression and may contribute to the identification of targeted therapies against AAV.

The research project is a collaboration between Lino Teichmann and Natalio Garbi, and is part of the newly funded SFB/Transregio 237 “Nucleic Acid Immunity”. The SFB/Transregio 237 is an interdisciplinary research network between the University of Bonn, the TU Dresden and the LMU Munich with participation of the University of Marburg, the TU Munich, and the MPI for Biochemistry in Munich. The SFB/TR 237 is well integrated into the excellent research infrastructure at the participating universities, including the Cluster of Excellence ImmunoSensation in Bonn.

The ideal candidate will be highly motivated and team-oriented with a strong interest in immunology and genetics. Experience with flow cytometry, histological and molecular biology techniques is advantageous. Experience in breeding and handling of genetically modified mice would also be useful. Candidates should hold a master’s degree or equivalent in Molecular Medicine, Biology, Pharmacy, Biochemistry or Veterinary Medicine. We offer a friendly and collaborative lab environment, supportive mentoring and a modern, well-equipped laboratory.

The position is available immediately, initially for 3 years with the possibility of extension. The salary will be according to the German salary scale TV-L (PhD students 65%, German TV-L E13). The University of Bonn is an equal opportunities employer. Preference will be given to suitably qualified women or persons with disabilities, all other considerations being equal. Candidates fulfilling the selection criteria will be interviewed in person.

Please submit your application (including CV, a motivation letter stating research and career interests, copies of education certificates, and two letters of recommendation or, alternatively the contacts for two referees) via email in a single PDF file.
Methoden: We utilize a broad range of assays including state of the art flow cytometry, multiplex confocal microscopy and gene expression profiling to analyze transgenic mouse strains carrying conventional knock-outs, point mutations and tissue-specific gene deletions.
Anfangsdatum: 11. August 2018
Geschätzte Dauer: 3 years
Bezahlung: TV-L E13 (65%)
Papers: https://www.ncbi.nlm.nih.gov/pubmed?term=Teichmann%20LL%5BAuthor%5D