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Archiv-Übersicht     Angebot Nr. 12986

Angebotsdatum: 20. August 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Cooperation between microtubule polymerases and gamma-tubulin

Institut: Zentrum für Molekulare Biologie
Adresse:
Frau Regina Tödter
INF 282
69120 Heidelberg
Tel.: 06221 546820   Fax.:
Bundesland: Baden-Württemberg
Homepage: http://https://www.zmbh.uni-heidelberg.de/schiebel/default.shtml
E-Mail Kontakt: mail

Beschreibung: The Centre of Molecular Biology of the University of Heidelberg (ZMBH) is looking for a

PhD candidate (f/m) – for the research project in „Cooperation between microtubule polymerases and gamma-tubulin “
(Centre for Molecular Biology Heidelberg University)

About the project:

Microtubules are highly dynamic polymers with essential functions in chromosome segregation in mitosis and meiosis, cell migration, transport and ciliogenesis. Drugs that target microtubules are used in cancer therapy indicating the therapeutic potential of the microtubule system.
Microtubules assemble through the polymerisation of tubulin at centrosomes. The gamma-tubulin complex (gamma-TuC) cooperates with the XMAP215/ch-TOG/Stu2 family of microtubule polymerases in microtubule assembly. Recently, we have shown (eLife, under revision) that the microtubule polymerase Stu2 directly interacts with the gamma-TuC in order to add the first tubulin molecules to the gamma-tubulin ring. Here we will extend this work to the structural and functional analysis of gamma-tubulin complexes with bound microtubule polymerase.

Your profile:
The PhD student will use biochemical approaches, super resolution microscopy (STED), electron microscopy (negative stain and cryo-EM), CRISPR/Cas9 technology and live cell imaging to study microtubules assembly in yeast and human cells.
Highly motivated PhD students with a background in biochemistry, cell biology or molecular biology should apply. Successful candidates will be part of an international team of PhD students and postdocs that works at the forefront of scientific research. The PhD student will be a member of the Heidelberg Biosciences International Graduate School (HBIGS) (http://www.hbigs.uni-heidelberg.de/).

We offer:
The PhD position is funded for 3 years with starting date based on mutual agreement (as soon as possible).
The remuneration is based on TV-L.
Please notice that the received application documents will not be returned.

Interested? How to apply:
Applications should be sent via Email to Prof. Elmar Schiebel (schiebel.elmar@zmbh.uni-heidelberg.de) and contain the following documents (in English): CV, motivation letter, two references.
We are looking forward to your application!
Methoden:
Anfangsdatum: 20. August 2018
Geschätzte Dauer: 3 Jahre
Bezahlung: TV-L
Papers:
Sonstiges: Relevant recent publications:
1 Ruthnick, D. & Schiebel, E. Duplication of the Yeast Spindle Pole Body Once per Cell Cycle. Mol Cell Biol 36, 1324-1331, doi:10.1128/MCB.00048-16 (2016).
2 Ruthnick, D. & Schiebel, E. Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body. Cells 7, doi:10.3390/cells7050042 (2018).
3 Seybold, C. et al. Kar1 binding to Sfi1 C-terminal regions anchors the SPB bridge to the nuclear envelope. J Cell Biol 209, 843-861, doi:10.1083/jcb.201412050 (2015).
4 Vlijm, R. et al. STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles. Proc Natl Acad Sci U S A 115, E2246-E2253, doi:10.1073/pnas.1716840115 (2018).
5 Zhang, W. et al. Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis. J Cell Biol 217, 877-894, doi:10.1083/jcb.201706024 (2018).

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