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Archiv-Übersicht     Angebot Nr. 12989

Angebotsdatum: 14. August 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Biochemie
Titel des Themas: Relevance of voltage-gated sodium channels for the perception of pain

Institut: Clinic for Anesthesiology and Intensive Care
Prof. Enrico Leipold
Ratzeburger Allee 160
23562 Lübeck
Tel.: +49 451 3101 8610   Fax.: +49 451 3101 8614
Bundesland: Schleswig-Holstein
E-Mail Kontakt: mail

Beschreibung: Nociceptive afferents (pain receptors) operate voltage-gated sodium channels (NaV channels) to translate pain signals into action potentials and to send these signals to the central nervous system. Recently, we demonstrated that functional alterations of sodium channel type NaV1.9 cause in affected patients either congenital analgesia or severe episodic pain attacks (Nat Genet 45: 1399-1404; Nat comm 6: 10049). It is still unknown how functionally altered NaV1.9 channels can cause these two completely opposing phenotypes. The aim of this project is to identify the molecular mechanisms underlying the opposing NaV1.9-dependent pain phenotypes congenital analgesia and severe episodic pain attacks.

Our offer:

We offer excellent working conditions in a motivating environment and a salary according to the german salary scale TV-L13 (65 %), initially limited to 3 years.

Your profile:

We are looking for an enthusiastic and highly motivated candidate who holds a master degree (or equivalent) in biology, biochemistry, biophysics, molecular life sciences, medicine or a similar subject and who has a strong interest to work on interdisciplinary scientific questions. In addition we expect good laboratory and communication skills and a targeted way of working.

Your application:

The University of Lübeck is an equal opportunity employer. People with disabilities will be given preference in case of equal qualification.
For further information on the position, please contact Prof. Dr. Enrico Leipold. Please send your application including a complete CV, a motivation letter, the contact details of two academic referees and (optional) a recommendation letter as a single pdf file (max. 4 MB) to:

Prof. Dr. Enrico Leipold
Neurowissenschaften in der Anästhesiologie
Universität zu Lübeck
CBBM – Center of Brain, Bahaviour and Metabolism, Haus 66
Ratzeburger Allee 160
23562 Lübeck
Tel: +49 451 3101 8610
Fax: +49 451 3101 8614
Mail: enrico.leipold@uni-luebeck.de
Methoden: The project will make use of state-of-the-art electrophysiological assays (patch-clamp technique) as well as of molecular biology methods (e.g. PCR-based DNA mutagenesis), culturing and transfection of mammalian cells and the isolation of primary neurons from tissue. All methods are well established in the group.
Anfangsdatum: 1. Oktober 2018
Geschätzte Dauer: 3 years
Bezahlung: according to german salary scale TV-L13 (65%)
Papers: Nat Genet 45: 1399-1404
Nat comm 6: 10049