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Archiv-Übersicht     Angebot Nr. 13011

Angebotsdatum: 25. August 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: Role of C-type-lectin receptors in Legionella pneumophila infection

Institut: Infectious Diseases and Pulmonary Medicine, Charité Berlin
Adresse:
Dr. rer. nat. Susann Beetz
Chariteplatz 1
10117 Berlin
Tel.: +493028460160   Fax.:
Bundesland: Berlin
Homepage: http://https://www.zibi-berlin.de/application/phd-projects/index.html
E-Mail Kontakt: mail

Beschreibung: Legionella pneumophila is an intracellular bacterium which can cause a severe pneumonia after inhalation of contaminated water droplets and replication in alveolar macrophages. The innate immune system is generally able to sense and -in most cases- control the infection, but comorbidities and genetic risk factors can compromise its capacity. This project aims at examining the role of C-type lectin receptors (CLRs) in L. pneumophila infection. Preliminary data show that a specific CLR protein is able to bind to the bacterium, and that this interaction regulates antibacterial immunity. The proposed PhD involves a further characterization of the underlying molecular mechanisms, study of its role during L. pneumonia in vivo, and investigation of genetic variants of the human CLR protein.
Methoden:
Anfangsdatum: 1. Mai 2019
Geschätzte Dauer: 3 - 4 Jahre
Bezahlung: übliche Doktorandenstelle
Papers:
Sonstiges: We only accept applications though our application portal! Deadline is October 7th, 2018.
This PhD position will be implementes in our Graduate School:
ZIBI Graduate School Berlin / Research in the fields of Infection Biology and Immunology
For more information, please use our website:
https://www.zibi-berlin.de/index.html

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