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Angebotsdatum: 25. August 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Quasiherpes – the role of genetic diversity in the evolution of large DNA viruses

Institut: Institute of Virology, Department for Veterinary Medicine, FU Berlin
Adresse:
Dr. rer. nat. Susann Beetz
Chariteplatz 1
10117 Berlin
Tel.: +493028460160   Fax.:
Bundesland:
Homepage: http://https://www.zibi-berlin.de/application/phd-projects/index.html
E-Mail Kontakt: mail

Beschreibung: This project is aimed at understanding the emergence and impact of genetic diversity on evolution and pathogenicity of large DNA viruses. We will make use of Marek’s disease virus (MDV), a chicken alphaherpesvirus, which we genetically modified to increase its genetic variability by impairing its proofreading capabilities during DNA replication. Advanced next generation sequencing (NGS) techniques will be used to determine mutation rates and population diversity in presence and absence of the exonuclease that is encoded in the viral polymerase. Characteristics of virus populations arising from low-fidelity replication will be determined in vitro and in vivo. The availability of the chicken as natural host of MDV will allow unprecedented analysis of the consequences of hyperdiversity for herpesvirus pathogenesis.
Methoden:
Anfangsdatum: 1. Mai 2019
Geschätzte Dauer: 3 - 4 Jahre
Bezahlung: übliche Doktorandenstelle
Papers:
Sonstiges: We only accept applications though our application portal! Deadline is October 7th, 2018.
This PhD position will be implementes in our Graduate School:
ZIBI Graduate School Berlin / Research in the fields of Infection Biology and Immunology
For more information, please use our website:
https://www.zibi-berlin.de/index.html

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