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Archiv-Übersicht     Angebot Nr. 13026

Angebotsdatum: 3. September 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Genetik
Titel des Themas: Epigenetic modifications in hematopoietic differentiation and leukemia

Institut: Uniklinik Aachen; Stammzellbiologie und Cellular Engineering
Prof. Wolfgang Wagner
Pauwelsstrasse 20
52078 Aachen
Tel.: 0241 8088611   Fax.:
Bundesland: Nordrhein-Westfalen
Homepage: http://www.stemcellbiology.ukaachen.de
E-Mail Kontakt: mail

Beschreibung: We are particularly interested in DNA methylation changes during directed differentiation, aging, and leukemic transformation. Our preliminary data indicate that the DNA methylation patterns of neighboring CpG sites are patient specific and can be used to track minimal residual disease in acute myeloid leukemia (AML). We want to develop this method further with new sequencing approaches. Furthermore, epigenetic writers and relevant proteins for chromatin structure will be modified with CRISPR-Cas9n technology and overexpression to determine their impact on the epigenetic makeup in malignant transformation.
Methoden: All relevant techniques are established in the lab (including culture expansion, differentiation assays, flow cytometry, immunofluorescence and confocal microscopy, qRT-PCR, blotting techniques, genetic modifications, microarray platforms, and epigenetic analysis with deep sequencing Technology).

We offer a highly interactive and well equipped environment in a team with international partners, a broad spectrum of methods, and a highly relevant topic.
Anfangsdatum: 1. November 2018
Geschätzte Dauer: 3 - 4 Jahre
Bezahlung: 65% TVL-E13
Papers: https://www.researchgate.net/profile/Wolfgang_Wagner4
Sonstiges: We are looking for a highly motivated and ambitious PhD student with a strong background in cell biology or epigenetics. Experience in bioinformatics would be appreciated. Willingness for teamwork, the ability to work independently, and excellent English language skills are a prerequisite.

Funding is available for at least three years: for the first year with 50% TV-L E13 and for the second and third year with 65% TV-L E13.

The RWTH Aachen University is certified as a family-friendly university and offers a dual career program for partner hiring. We particularly welcome and encourage applications from women, disabled people and ethnic minority groups, recognizing they are underrepresented across RWTH Aachen University. The principles of fair and open competition apply and appointments will be made on merit.

Your application should include a cover letter which specifically emphasizes your interest in our work (preferably in English), CV, and copies of the most important certificates. For additional questions please contact Prof. Dr. Dr. Wolfgang Wagner. Your application should be send by Email until September 28th, 2018 (wwagner@ukaachen.de).

We are looking forward to your application!