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Archiv-Übersicht     Angebot Nr. 13060

Angebotsdatum: 26. September 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Neurobiologie
Titel des Themas: Neurodegeneration, dementia & rare genetic neurologic disease

Institut: Institut für Humangenetik / CMMC, Uniklinik Köln
Herr Hans MD PhD MSc
Kerpener Str. 34
50931 Köln
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
Homepage: http://humangenetik-koeln.de
E-Mail Kontakt: mail

Beschreibung: The Institute of Human Genetics, Cologne University Clinic is seeking applications for one
PhD (Dr. rer. nat. / Dr. nat. med.) Student (f/m)
to be employed under a limited-time contract of 3 years, to start as soon as possible. We are
searching for motivated scientists interested in the area of Neurodegeneration, dementia & rare genetic neurologic disease to join the laboratory of Functional Neurogenetics and Neurodegeneration under the lead of Hans Zempel, MD PhD. Previous experience in molecular biology is advantageous, but no prerequisite.
Methoden: Methods that will be used comprise, but are not limited to state of the art cellular neurobiology / cell biology, biochemistry, molecular biology / genomics, and advanced microscopy.
Anfangsdatum: 15. Oktober 2018
Geschätzte Dauer: 3 years
Bezahlung: 1600,00€ (stipend)
Papers: Selected Publications
Zempel H, Dennissen FJA, Kumar Y, Luedtke J, Biernat J, Mandelkow EM, Mandelkow E.
Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture.
J Biol Chem. 2017 Jul 21;292(29):12192-12207. doi: 10.1074/jbc.M117.784702. Epub 2017 May 23.
PubMed PMID: 28536263

Zempel H, Sadzot B and Haag N.
Treatment Avenues for the Juvenile and Adult Onset Mitochondriopathies Alpers Syndrome, Ataxia Neuropathy Spectrum, MEMSA and PEO Caused by Polymerase-Gamma Mutations Ala467Thr and Trp748Ser.
SM J Neurol Neurosci. 2017; 3(2): 1013. Review.

Zempel H, Mandelkow EM.
Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia.
Mol Neurodegener. 2015 Dec 21;10:68. doi: 10.1186/s13024-015-0064-1. Review.
PubMed PMID: 26691836

Zempel H, Mandelkow E.
Lost after translation: missorting of Tau protein and consequences for Alzheimer disease.
Trends Neurosci. 2014 Dec;37(12):721-32. doi: 10.1016/j.tins.2014.08.004. Epub 2014 Sep 12. Review.
PubMed PMID: 25223701

Zempel H, Luedtke J, Kumar Y, Biernat J, Dawson H, Mandelkow E, Mandelkow EM.
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin.
EMBO J. 2013 Nov 13;32(22):2920-37. doi: 10.1038/emboj.2013.207. Epub 2013 Sep 24.
PubMed PMID: 24065130

Li X, Kumar Y, Zempel H, Mandelkow EM, Biernat J, Mandelkow E.
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.
EMBO J. 2011 Oct 18;30(23):4825-37. doi: 10.1038/emboj.2011.376.
PubMed PMID: 22009197

Timm T, von Kries JP, Li X, Zempel H, Mandelkow E, Mandelkow EM.
Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential.
J Biol Chem. 2011 Dec 2;286(48):41711-22. doi: 10.1074/jbc.M111.257865. Epub 2011 Oct 7.
PubMed PMID: 21984823

Zempel H, Thies E, Mandelkow E, Mandelkow EM.
Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines.
J Neurosci. 2010 Sep 8;30(36):11938-50. doi: 10.1523/JNEUROSCI.2357-10.2010. Erratum in: J Neurosci. 2012 Apr 25;32(17):6052.
PubMed PMID: 20826658
Sonstiges: PhD students will be enrolled in the graduate school “Interdisciplinary Program Molecular
Medicine” of the University of Cologne, Faculty of Medicine and Faculty of Mathematics and
Natural Sciences (for Dr. nat. med., see https://www.cmmc-uni-koeln.de/ipmm/overview/ for details), or at the “Graduate School for Biological Sciences” of the Faculty of Mathematics and Natural Sciences, University Cologne (for Dr. rer. nat., see http://www.gs-biosciences.uni-koeln.de/ for details), both of which offer a structured education platform.
Our laboratories are located within the CMMC (http://www.cmmc-uni-koeln.de/home), which offers a stimulating environment itself, but also the vicinity to CECAD (http://cecad.uni-koeln.de/Home.393.0.html), Max-Planck Institute for Aging and the Cologne University & University Clinic allows fruitful
collaborations. The University of Cologne offers a wide range of scientific disciplines and internationally leading profile areas organized in six faculties. At the Faculty of Medicine 1.800 scientists are engaged in
research, ranging from basic sciences to clinical application, as well as teaching and health care. Together with the University Hospital Cologne the faculty maintains 58 clinics, research institutes and centres. 3.400
students study in this dynamic and innovative environment. The Faculty of Medicine and the University Hospital Cologne are embedded in the scientifically highly active Rhine region. They have strong contacts to and alliances with the surrounding universities and non-university research institutions guaranteeing scientific excellence in research and teaching. Applications from female candidates are welcome; suitably qualified women will be given preferential consideration unless other applicants clearly demonstrate superior qualifications. We also welcome applications from disabled candidates, who will also be given preferential consideration over other applicants with comparable qualifications.
If you want to do cool science, are interested in understanding and treating neurologic disease, please send your online application as one single PDF-file to including cover letter, CV, scientific experience, motivation letter and contact information of two referees to:
For more information please visit our website: http://humangenetik-koeln.de