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Archiv-Übersicht     Angebot Nr. 13099

Angebotsdatum: 23. Oktober 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: “Deciphering fibroblast – macrophage crosstalk in arthritis”

Institut: Molekulare Endokrinologie der Tiere
Adresse:
Frau Jennifer Laufer
Helmholtzstr. 8/1
89081 Ulm
Tel.: 0731 50 32601   Fax.: 0731 50 32609
Bundesland: Baden-Württemberg
Homepage: http://https://www.uni-ulm.de/nawi/cme/
E-Mail Kontakt: mail

Beschreibung: The Tuckermann Lab at the Instiute for Comparative Molecular Endocrinology/Ulm University (Director: Prof. Dr. Jan Tuckermann) is looking for a PhD student studying molecular mecha-nisms of fibroblast – macrophage crosstalk” in vivo.
Rheumatoid arthritis are chronic inflammatory diseases of the joints that are associated with pain and irreversible joint destruction. Arthritic diseases are frequently treated with glucocorti-coids (e.g. cortisol and pharmacological derivatives) due to their strong immune suppressive effects. But the usefulness of glucocorticoid therapy is hampered by severe side effects such as diabetes and osteoporosis. Defining the mechanism how glucocorticoids reduce the inflammato-ry burden and the detrimental effects in bone is therefore decisive for new treatment strategies to optimize or replace glucocorticoid therapy. We recently reported a novel molecular mecha-nism of anti-inflammatory activity of glucocorticoids involving glucocorticoid receptor (GR) dimerization in non-immune stromal cells to induce con-classical anti-inflammatory polari-zation of macrophages (Ann Rheum Dis 2018, doi: 10.1136/annrheumdis-2017-212762). We now provide the paradigm shifting observation that reducing cytokine expression is not sufficient for reducing inflammation, but rather modulation of synovial fibroblast crosstalk to the innate immune system, such as macrophages is the key process to resolve inflammation.

Applicants are invited to apply by sending a letter of interest, CV and contact details of two ref-erees in a single PDF file by email to: jan.tuckermann@uni-ulm.de latest November 15th 2018.
Please indicate the index number 121. According to German law, disabled persons with equal occupational aptitude will be given preferred consideration.

Methoden: The Tuckermann Lab at the Instiute for Comparative Molecular Endocrinology/Ulm University (Director: Prof. Dr. Jan Tuckermann) is looking for a PhD student studying molecular mecha-nisms of fibroblast – macrophage crosstalk” in vivo.
Rheumatoid arthritis are chronic inflammatory diseases of the joints that are associated with pain and irreversible joint destruction. Arthritic diseases are frequently treated with glucocorti-coids (e.g. cortisol and pharmacological derivatives) due to their strong immune suppressive effects. But the usefulness of glucocorticoid therapy is hampered by severe side effects such as diabetes and osteoporosis. Defining the mechanism how glucocorticoids reduce the inflammato-ry burden and the detrimental effects in bone is therefore decisive for new treatment strategies to optimize or replace glucocorticoid therapy. We recently reported a novel molecular mecha-nism of anti-inflammatory activity of glucocorticoids involving glucocorticoid receptor (GR) dimerization in non-immune stromal cells to induce con-classical anti-inflammatory polari-zation of macrophages (Ann Rheum Dis 2018, doi: 10.1136/annrheumdis-2017-212762). We now provide the paradigm shifting observation that reducing cytokine expression is not sufficient for reducing inflammation, but rather modulation of synovial fibroblast crosstalk to the innate immune system, such as macrophages is the key process to resolve inflammation.
Anfangsdatum: 16. Januar 2019
Geschätzte Dauer: 3 years and will be extended upon evaluation.
Bezahlung: salary level according to TVLE13 (65%)
Papers:
Sonstiges: We offer an enthusiastic international team and strong interactions with the other research groups at the institute, the university campus (CRC 1149 Trauma) and many international coop-erations. The position is enrolled in the International Graduate School in Molecular Medicine in Ulm with courses in state-of-the-art techniques and soft skills and support for conference visits (https://www.uni-ulm.de/einrichtungen/mm/).
The position starts from January 16th 2019 on a salary level according to TVLE13 (65%) for 3 years and will be extended upon evaluation.

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