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Archiv-Übersicht     Angebot Nr. 13106

Angebotsdatum: 29. Oktober 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: PhD Position in Immune Cell Biology

Institut: Biomedical Center Munich (BMC), Ludwig-Maximilians Universität München
Prof. Jörg Renkawitz
Großhaderner Str. 9
82152 Planegg-Martinsried
Tel.:    Fax.:
Bundesland: Bayern
Homepage: http://www.wbex.med.uni-muenchen.de/pages/principal_j_renkawitz.htm
E-Mail Kontakt: mail

Beschreibung: Do you know that some immune cells can take up the equivalent of their own volume in one hour? Do you know that there are at least 500 billion immune cells constantly migrating through your body? In your lifetime, their cumulative distance would make it roughly once across our solar system! Interested in how cells perform these miraculous tasks? Then join our team efforts to decipher the underlying mechanisms!

We are a young and newly established research group using immune cells (e.g. dendritic cells, macrophages & neutrophils) as model cell types to discover novel cell biological principles in cell motility (macropinocytosis, cell migration, leukocyte trafficking). We interdisciplinary combine advanced live-cell microscopy, genetic-engineering (e.g. CRISPR), custom-made microenvironments (e.g. microfluidics), system-wide approaches (e.g. screening) and immune cell culture (see e.g. Renkawitz et al, Methods Cell Biology 2018, Hons et al, Nature Immunology 2018, Renkawitz & Sixt, 2016, Renkawitz et al, Nature Cell Biology 2009). In your PhD project you will use different cellular models of immune cells (mammalian cell lines and primary mouse cells) to characterize the spatiotemporal dynamics of macropinocytosis and its associated proteins by fluorescent live cell imaging. In parallel, you will establish molecular, genetic and screening approaches to identify the molecular factors and mechanisms driving macropinocytosis. Thereby, your PhD project will provide an important contribution to the understanding of how immune cells sample their microenvironment to regulate immune responses in physiology and disease.

Are you open-minded, self-driven, interested in science, and a team-player? Do you have a background in molecular biology, cell biology or immunology with experience in imaging, cell culture, or molecular approaches (cloning, CRISPR)? We are looking for a talented and motivated PhD student to join our team at the next possible date. Our group is located in the modern building of the Biomedical Center Munich (BMC) of the LMU Munich, integrated into the stimulating environment of the SFB914 “Trafficking of Immune Cells in Inflammation, Development and Disease”. You will further have the possibility to participate in the graduate program ‘Leukocyte Trafficking’ of the SFB914. We provide an excellent environment, facilities and supervision in a young, motivated team.

For further information see:
Homepage: http://www.wbex.med.uni-muenchen.de/pages/principal_j_renkawitz.htm
Twitter: @renkawitzteam
Publications: https://www.ncbi.nlm.nih.gov/pubmed/?term=renkawitz+j
SFB914: https://www.sfb914.med.uni-muenchen.de/index.html
Biomedical Center Munich: https://www.en.bmc.med.uni-muenchen.de/index.html

Please send your application including your covering letter, CV, certificates and two reference contacts in one PDF to Joerg.Renkawitz@med.uni-muenchen.de. We are looking forward to your application!
Methoden: advanced live-cell microscopy, genetic-engineering (e.g. CRISPR), custom-made microenvironments (e.g. microfluidics), system-wide approaches (e.g. screening) and immune cell culture
Anfangsdatum: 29. Oktober 2018
Geschätzte Dauer: 3/4 Jahre