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Archiv-Übersicht     Angebot Nr. 13108

Angebotsdatum: 29. Oktober 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Pharmakologie
Titel des Themas: ADAM proteases in inflammatory diseases

Institut: Experimentelle und Klinische Pharmakologie und Toxikologie/PZMS
Prof. Daniela Yildiz
Kirrbergerstr. Gebäude 46
66421 Homburg
Tel.:    Fax.:
Bundesland: Saarland
Homepage: http://www.pzms.uni-saarland.de/index.php/jun-prof-yildiz
E-Mail Kontakt: mail

Beschreibung: We are a young research group working on the function of ADAM proteases and transmembrane chemokines in acute and chronic inflammatory diseases. Many mediators of the inflammatory response are expressed as transmembrane proteins and are cleaved by the activity of the ‘a disintegrin and metalloproteinases’ (ADAMs). This process close to the plasma membrane releasing a soluble ectodomain is called shedding. Our research is focused on ADAM8, ADAM10, ADAM15 and ADAM17 seeking for their ‘interacting Eves’ and their relevance in inflammatory processes of the lung and the cardiovascular system, for example infection. Looking at the thematic focuses of our institute you can imagine that this is not the only apple which we have to offer. That’s where we need your support!

We offer...
- two PhD positions (in house/third-party funding)
- broad range of techniques both in vitro and in vivo (molecular biology, biochemistry, FACS, calcium imaging/patch clamp, mass spectrometry, sterile and infectious inflammation a.s.o.)
- small campus with short distances and strong collaborations
- perfect environment and support for families (https://www.uni-saarland.de/page/audit/start.html)
- low cost of living
In summary we offer a research paradise immersed in nature.

You bring along...
- degree in biology, biotechnology, human biology or related disciplines
- broad expertise in state of the art techniques (i.a. cloning, PCR, RT-qPCR, Western blot, ELISA, cell culture)
- sense for collaborative work and team work
- strong responsibility
- flexibility
- autonomous working.
Experience in animal experiments is a plus but not required.

For further information, please have a look on http://www.pzms.uni-saarland.de/index.php/jun-prof-yildiz.

Please send your online application including your certificates, a summary of your master thesis and previous lab work as well as at least one reference letter to daniela.yildiz@uks.eu (Jun.-Prof. Dr. rer. nat. Daniela Yildiz née Dreymueller, Saarland University/University Hospital, Homburg).
Anfangsdatum: 29. Oktober 2018
Geschätzte Dauer: 3 Jahre
Bezahlung: TVL13/2