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Archiv-Übersicht     Angebot Nr. 13109

Angebotsdatum: 30. Oktober 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Ph.D. Position to Study Nuclear mRNA Packaging as part of an ERC-Funded Project

Institut: Institut für Biochemie
Adresse:
Prof. Katja Sträßer
Heinrich-Buff-Ring 17
35392 Gießen
Tel.:    Fax.:
Bundesland: Hessen
Homepage: http://https://www.uni-giessen.de/fbz/fb08/Inst/biochem/straesser
E-Mail Kontakt: mail

Beschreibung: We are looking for highly motivated Ph.D. students to work on the ERC-funded project “Nuclear mRNA Packaging and mRNP Architecture” beginning as soon as possible. Already during transcription by RNA polymerase II the synthesized mRNA is bound by nuclear RNA-binding proteins and packaged into a messenger ribonucleoprotein particle (mRNP). This process is of prime importance for correct gene expression as it is necessary for stability and nuclear export of the mRNA and even determines cytoplasmic steps such as translation and mRNA degradation. In addition, defects in mRNP packaging lead to diseases. However, the mechanism of mRNA packaging and the structure of an mRNP are not known, and, thus, will be elucidated in this project.
Methoden: Purification of specific mRNPs and their biochemical and structural analysis: affinity purification, RNA biology, protein purification, in vivo analysis, qPCR, gene expression, FISH, mRNA export
Anfangsdatum: 30. November 2018
Geschätzte Dauer: 4 Jahre (Doktorarbeit), 4 years
Bezahlung: according to TV-H
Papers:
Sonstiges:

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